Popescu Dan P, Choo-Smith Lin-P'ing, Flueraru Costel, Mao Youxin, Chang Shoude, Disano John, Sherif Sherif, Sowa Michael G
National Research Council of Canada, Institute for Biodiagnostics, 435 Ellice Avenue, Winnipeg, MB, Canada, R3B 1Y6.
National Research Council of Canada, Institute for Microstructural Sciences, 1200 Montreal Road, Ottawa, ON, Canada, K1A 0R6.
Biophys Rev. 2011 Sep;3(3):155. doi: 10.1007/s12551-011-0054-7. Epub 2011 Aug 6.
The advances made in the last two decades in interference technologies, optical instrumentation, catheter technology, optical detectors, speed of data acquisition and processing as well as light sources have facilitated the transformation of optical coherence tomography from an optical method used mainly in research laboratories into a valuable tool applied in various areas of medicine and health sciences. This review paper highlights the place occupied by optical coherence tomography in relation to other imaging methods that are used in medical and life science areas such as ophthalmology, cardiology, dentistry and gastrointestinal endoscopy. Together with the basic principles that lay behind the imaging method itself, this review provides a summary of the functional differences between time-domain, spectral-domain and full-field optical coherence tomography, a presentation of specific methods for processing the data acquired by these systems, an introduction to the noise sources that plague the detected signal and the progress made in optical coherence tomography catheter technology over the last decade.
在过去二十年中，干涉技术、光学仪器、导管技术、光学探测器、数据采集与处理速度以及光源等方面取得的进展，推动光学相干断层扫描技术从主要用于研究实验室的光学方法，转变为应用于医学和健康科学各个领域的宝贵工具。这篇综述文章重点介绍了光学相干断层扫描技术相对于其他用于医学和生命科学领域（如眼科、心脏病学、牙科和胃肠内窥镜检查）的成像方法所占据的地位。除了成像方法本身背后的基本原理外，本综述还总结了时域、频域和全场光学相干断层扫描之间的功能差异，介绍了处理这些系统采集的数据的具体方法，介绍了困扰检测信号的噪声源以及过去十年光学相干断层扫描导管技术取得的进展。
