O'Malley K, Docherty J R, Kelly J G
Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, Dublin.
J Hypertens Suppl. 1988 Nov;6(1):S59-62.
Adrenoceptor function is an important determinant of the physiological control of the circulation and of the response to drugs acting via the sympathetic nervous system and on the vasculature. There is little consistent evidence for an age-dependent change in alpha-adrenoceptor function though the response to various vasoconstrictor agents including alpha 1 agonists has been shown to change with ageing. These changes seem to reflect structural or functional factors and are not specific for receptor types. In the case of beta-adrenoceptor mediated responses there is evidence for both a decrease in response as well as age-related changes in the functioning of various components of the beta-adrenoceptor system, including receptor affinity, which is decreased. It may well be that decreased beta-adrenoceptor function with ageing contributes to altered cardiovascular control and to decreased efficacy of beta-adrenoceptor blocking drugs in elderly hypertensives.
肾上腺素能受体功能是循环系统生理调控以及对通过交感神经系统作用于血管系统的药物产生反应的重要决定因素。虽然已表明对包括α1激动剂在内的各种血管收缩剂的反应会随年龄增长而变化，但关于α肾上腺素能受体功能随年龄变化的一致证据很少。这些变化似乎反映了结构或功能因素，并非特定于受体类型。就β肾上腺素能受体介导的反应而言，有证据表明反应降低以及β肾上腺素能受体系统各组分功能出现与年龄相关的变化，包括受体亲和力降低。很可能随着年龄增长β肾上腺素能受体功能下降导致心血管调控改变以及β肾上腺素能受体阻断药在老年高血压患者中的疗效降低。
