Ntanasis-Stathopoulos Ioannis, Tsilimigras Diamantis I, Georgiadou Despoina, Kanavidis Prodromos, Riccioni Olga, Salla Charitini, Psaltopoulou Theodora, Sergentanis Theodoros N
Department of Clinical Therapeutics, Alexandra Hospital, National and Kapodistrian University of Athens, Athens, Greece; Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Eur J Cancer. 2017 Jul;79:193-204. doi: 10.1016/j.ejca.2017.04.006. Epub 2017 May 13.
The diagnosis and treatment of squamous cell carcinoma of the pancreas pose dilemmas in the clinical practice. The present study was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Eligible articles were sought in MEDLINE up to 30th April 2016. A pooled Cox regression analysis was performed to evaluate factors potentially associated with overall survival (OS) and relapse-free survival (RFS). Fifty-four cases of pure squamous cell pancreatic carcinomas were identified in total. The mean age was 61.9 years, and most patients were males (61.1%). The median OS was 7 months. Resectability (p = 0.003) and more recent publication year (p < 0.001) were associated with better OS, as was low/intermediate tumour grade (p = 0.032) with RFS. Despite its poor prognosis, survival rates of pancreatic squamous cell carcinoma seem improved during the recent years; resectability and low/intermediate grade emerged as favourable prognostic factors. Collaborative epidemiological studies are deemed necessary to further validate the results stemming from the published case reports of this rare entity.
胰腺鳞状细胞癌的诊断和治疗在临床实践中存在诸多难题。本研究按照系统评价和Meta分析的首选报告项目指南进行。截至2016年4月30日，在MEDLINE中检索符合条件的文章。进行汇总Cox回归分析以评估可能与总生存期（OS）和无复发生存期（RFS）相关的因素。共识别出54例纯胰腺鳞状细胞癌病例。平均年龄为61.9岁，大多数患者为男性（61.1%）。中位总生存期为7个月。可切除性（p = 0.003）和更近的发表年份（p < 0.001）与更好的总生存期相关，低/中度肿瘤分级（p = 0.032）与无复发生存期相关。尽管预后较差，但近年来胰腺鳞状细胞癌的生存率似乎有所提高；可切除性和低/中度分级成为有利的预后因素。认为有必要开展协作性流行病学研究，以进一步验证来自这种罕见实体已发表病例报告的结果。
