[The diagnostics and clinical pattern of nonalcoholic fatty liver disease in patients with pre-diabetes and type 2 diabetes and obesity].

INTRODUCTION

The data of epidemiological researches confirm the tendency in increasing of non alcoholic fatty liver disease (NAFLD) in patients with insulin resistance which occurs because of obesity, diabetes type 2 and metabolic syndrome.

AIM

Optimization of diagnostic and treatment efficacy in patients with non alcoholic steatosis and steatohepatitis on the background of obesity.

MATERIALS AND METHODS

General clinical examination of patients, laboratory and instrumental methods ( fatty liver index, non invasive assessment of liver, morphology, electrocardiography, treadmillergometry, ultrasound examination of abdominal organs, liver elastography,CT,MRI, methods of statistical analysis.

RESULTS

NAFLD was diagnosed in 98.4% of patients with diabetes type 2, from which steatosis was found in 54.84% and steatohepatitis in 45.16%. In individuals with prediabetes NAFLD was in 70.5%, of which 85.45% with steatosis and 14.55% steatohepatitis (p<0.05). The clinical picture of patients with NAFLD prevailed such symptoms and complaints: flatulence in 43.59% of patients, weakness and pain in the right upper quadrant in 29.9% of patients. Fewer patients complained on discomfort in abdomen 28.21%, constipation 21.37% and feeling of bitterness in the mouth 21.37%.

CONCLUSION

Clinical features of NAFLD are polysymptomatic. There are prevalence of dyspeptic syndromes (bloating met in 43.59% of patients, pain in right upper quadrant and discomfort in abdomen -29.91%, constipation- 28.21%, bitterness in mouth-21.37%. Determination of fatty liver index is very informative method of screening patients with hepatisteatosis.