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一例源自颊黏膜疣状癌的巨大皮肤角:罕见病例报告

A Giant Cutaneous Horn Projecting from Verrucous Carcinoma of Buccal Mucosa: A Rare Case Report.

作者信息

Singh Priyankar, Nathani Dipesh, Ranjan Shashi, Issar Rashmi

机构信息

Senior Resident, Department of Dentistry, Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India.

Private Practitioner, Dr Nathani's Dentofacial CareSurat, Gujarat, India.

出版信息

J Clin Diagn Res. 2017 Mar;11(3):ZD04-ZD05. doi: 10.7860/JCDR/2017/24657.9361. Epub 2017 Mar 1.

Abstract

Cutaneous horn is conical shape of compact keratin that resembles a miniature animal horn. Though morphologically similar to horns in animals they are histologically very different from them. It is a circumscribed, conical, hyperkeratotic dense protrusion with epithelial cornification above the skin surface in response to a wide range of underlying benign and malignant pathological changes. Though benign, a cutaneous horn holds the potential to be premalignant or malignant. In India till now six cases has been reported with cutaneous horn at various unusual sites. We report a unique case of 52-year-old woman with a giant cutaneous horn at left oral commissure with underlying verrucous carcinoma of left buccal mucosa which is a very rare location for such lesion. Considering its malignant potential, adequate therapy requires wide excision with a tumour-free margin of at least 1 cm, particularly in the facial region where the incidence of malignancy is higher.

摘要

皮肤角是一种致密角蛋白构成的圆锥形结构,形似微型动物角。尽管在形态上与动物的角相似,但它们在组织学上与动物角有很大不同。它是一种局限性的、圆锥形的、角化过度的致密突出物,是皮肤表面上皮角化对多种潜在的良性和恶性病理变化的反应。虽然皮肤角是良性的,但有恶变或恶性的可能。在印度,迄今已报道了6例皮肤角出现在各种不寻常部位的病例。我们报告了一例独特的病例,一名52岁女性,左侧口角处有一个巨大的皮肤角,其下方为左侧颊黏膜疣状癌,这是该病变非常罕见的部位。鉴于其恶变潜能,充分的治疗需要进行广泛切除,切缘至少有1 cm无肿瘤组织,特别是在恶性发生率较高的面部区域。

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本文引用的文献

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Multiple cutaneous horns due to discoid lupus erythematosus.盘状红斑狼疮所致多发性皮肤角质瘤
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Br J Dermatol. 1951 Aug-Sep;63(8-9):323-4. doi: 10.1111/j.1365-2133.1951.tb13734.x.
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Cutaneous horn occurring on the lip of a child.发生于儿童唇部的皮肤角。
Int J Paediatr Dent. 2003 Sep;13(5):365-7. doi: 10.1046/j.1365-263x.2003.00481.x.

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