Li Weijie, Xiao Yeyu
a School of Chemical and Environmental Engineering , Hanshan Normal University , Chaozhou , P.R. China.
b The Second Affiliated Hospital, College of Medicine , Shantou University , Shantou , P.R. China.
Nat Prod Res. 2018 Jan;32(1):48-53. doi: 10.1080/14786419.2017.1329729. Epub 2017 May 16.
Nine lupeol derivatives were synthesised and assayed in vitro for their antitumour activities against three human tumour cells lines, A549, LAC and HepG2. Of lupeol derivaties, six were new compounds, and five compounds against A549 cells, four compounds against HepG2 cells and three compounds against LAC cells were effective in reducing viability, and the most promising compounds 5, 6 and 9 exhibited high activities against lung and liver cancer cells, even higher activities than those of adriamycin.
合成了九种羽扇豆醇衍生物，并在体外测定了它们对三种人类肿瘤细胞系A549、LAC和HepG2的抗肿瘤活性。在羽扇豆醇衍生物中，有六种是新化合物，五种对A549细胞、四种对HepG2细胞和三种对LAC细胞有效的化合物可降低细胞活力，最有前景的化合物5、6和9对肺癌和肝癌细胞表现出高活性，甚至比阿霉素的活性还高。
