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双侧睾丸肿瘤的肿瘤睾丸精子提取术(onco-TESE):两例病例报告

Onco-testicular sperm extraction (onco-TESE) for bilateral testicular tumors: two case reports.

作者信息

Tsutsumi Sohgo, Kawahara Takashi, Takeshima Teppei, Chiba Sawako, Uemura Koichi, Otani Masako, Shimokihara Kota, Hayashi Yutaro, Mochizuki Taku, Takamoto Daiji, Hattori Yusuke, Teranishi Jun-Ichi, Miyoshi Yasuhide, Yao Masahiro, Inayama Yoshiaki, Yumura Yasushi, Uemura Hiroji

机构信息

Department of Urology/Renal Transplantation, Yokohama City University Medical Center, Yokohama, Japan.

Reproduction Center, Department of Urology, Yokohama City University Medical Center, Yokohama, Japan.

出版信息

J Med Case Rep. 2017 May 17;11(1):139. doi: 10.1186/s13256-017-1303-6.

DOI:10.1186/s13256-017-1303-6
PMID:28511670
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5434529/
Abstract

BACKGROUND

Most patients with testicular cancer are infertile; thus, the preservation of the sperm after surgery is an important factor to consider. We report two cases of bilateral testicular cancer in patients who underwent bilateral higher orchiectomy and simultaneous testicular sperm extraction.

CASE PRESENTATION

Two Asian-Japanese men were referred to our hospital with bilateral testicular tumors. Both of the patients were preoperatively diagnosed with azoospermia and requested testicular sperm extraction at the time of higher orchiectomy. In one patient, sperm was successfully harvested and then frozen. In the other patient, sperm could not be retrieved from the patient's testis. In both patients, the pathological diagnosis was seminoma. Testicular tumors often occur in patients of reproductive age. The preservation of sperm before chemotherapy or bilateral orchiectomy is necessary for patients with testicular tumors who wish to be fathers.

CONCLUSIONS

Onco-testicular sperm extraction might be an option for patients with testicular cancer and azoospermia or severe oligospermia.

摘要

背景

大多数睾丸癌患者会出现不育;因此,术后保留精子是一个需要考虑的重要因素。我们报告了两例双侧睾丸癌患者,他们接受了双侧高位睾丸切除术并同时进行了睾丸精子提取。

病例介绍

两名亚洲日本男性因双侧睾丸肿瘤转诊至我院。两名患者术前均被诊断为无精子症,并在高位睾丸切除术时要求进行睾丸精子提取。其中一名患者成功采集到精子并冷冻保存。另一名患者未能从其睾丸中获取精子。两名患者的病理诊断均为精原细胞瘤。睾丸肿瘤常发生于育龄期患者。对于希望成为父亲的睾丸肿瘤患者,在化疗或双侧睾丸切除术前保留精子是必要的。

结论

对于患有睾丸癌且无精子症或严重少精子症的患者,肿瘤睾丸精子提取可能是一种选择。

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本文引用的文献

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Andrologia. 2015 May;47(4):482-5. doi: 10.1111/and.12292. Epub 2014 May 20.
2
Predictors of spermatogenesis in orchiectomy specimens.睾丸切除术标本中精子发生的预测因素。
Urology. 2013 Feb;81(2):288-92. doi: 10.1016/j.urology.2012.10.038.
3
Onco-testicular sperm extraction: testicular sperm extraction in azoospermic and very severely oligozoospermic cancer patients.
Onco-TESE (Testicular Sperm Extraction): Insights from a Tertiary Center and Comprehensive Literature Analysis.
睾丸精子提取术(Onco-TESE):来自一个三级中心的见解和全面文献分析。
Medicina (Kaunas). 2023 Jun 29;59(7):1226. doi: 10.3390/medicina59071226.
4
Testicular sperm extraction (TESE) outcomes in the context of malignant disease: a systematic review.睾丸精子提取术(TESE)在恶性疾病中的结果:系统评价。
Asian J Androl. 2022 Nov-Dec;24(6):584-590. doi: 10.4103/aja2021129.
5
Editorial Comment to First report of testis-sparing surgery for sertoliform cystadenoma: case presentation and review of literature .
IJU Case Rep. 2021 Sep 20;4(6):428. doi: 10.1002/iju5.12378. eCollection 2021 Nov.
6
Bilateral Testicular Epidermoid Cysts in a Man with Klinefelter Syndrome: A Case Report.一名患有克兰费尔特综合征男性的双侧睾丸表皮样囊肿:病例报告
Cureus. 2020 Dec 1;12(12):e11834. doi: 10.7759/cureus.11834.
7
Fertility considerations in men with testicular cancer.睾丸癌男性的生育相关考量
Transl Androl Urol. 2020 Jan;9(Suppl 1):S14-S23. doi: 10.21037/tau.2019.08.08.
8
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Clin Exp Reprod Med. 2018 Mar;45(1):44-47. doi: 10.5653/cerm.2018.45.1.44. Epub 2018 Mar 30.
9
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Basic Clin Androl. 2018 Jan 25;28:1. doi: 10.1186/s12610-018-0066-2. eCollection 2018.
肿瘤睾丸精子提取术:无精子症和严重少精子症癌症患者的睾丸精子提取术。
Andrologia. 2013 Apr;45(2):107-10. doi: 10.1111/j.1439-0272.2012.01319.x. Epub 2012 Jun 12.
4
Management and outcome of bilateral testicular germ cell tumors: a 25-year single center experience.双侧睾丸生殖细胞肿瘤的管理与预后:一项25年的单中心经验
Int J Urol. 2008 Sep;15(9):821-6. doi: 10.1111/j.1442-2042.2008.02107.x. Epub 2008 Jul 23.
5
Testicular sperm extraction in a single cancerous testicle in patients with azoospermia: a case report.无精子症患者单个癌性睾丸的睾丸精子提取:病例报告
Fertil Steril. 2008 Aug;90(2):443.e1-4. doi: 10.1016/j.fertnstert.2007.07.1308. Epub 2007 Nov 26.
6
"Onco-tese": testicular sperm extraction in azoospermic cancer patients before chemotherapy-new guidelines?“肿瘤睾丸取精术”:化疗前无精子症癌症患者的睾丸精子提取——新指南?
Urology. 2003 Feb;61(2):421-5. doi: 10.1016/s0090-4295(02)02264-1.
7
Testicular dysgenesis syndrome: an increasingly common developmental disorder with environmental aspects.睾丸发育不全综合征:一种与环境因素相关且日益常见的发育障碍。
Hum Reprod. 2001 May;16(5):972-8. doi: 10.1093/humrep/16.5.972.