EA 4708 I3MTO, université d'Orléans, 45067 Orléans, France; Service de rhumatologie, CHR Orléans, 45032 Orléans, France.
EA 4708 I3MTO, université d'Orléans, 45067 Orléans, France; Service de rhumatologie, CHR Orléans, 45032 Orléans, France.
Joint Bone Spine. 2018 May;85(3):301-306. doi: 10.1016/j.jbspin.2017.04.012. Epub 2017 May 13.
Many imaging modalities have been described to diagnose and monitor osteoporosis (OP), osteoarthritis and inflammatory rheumatic diseases. Over the last ten years, High Resolution peripheral Quantitative Computerized Tomography (HR-pQCT) was shown to be a precise and non invasive technique to study bone and joint diseases in clinical research. It allows the study of both cortical and trabecular bone microarchitecture at the distal tibia and radius, and further applications have been developed such as the study of mechanical properties by the finite element analysis. Thus, in case-control and cross-sectional studies, microarchitecture parameters discriminated fractured individuals independently of areal BMD. Also, microstructure parameters can predict incident fracture in postmenopausal women. In metabolic diseases associated with bone fragility, HR-pQCT may also be used to explore bone changes. In joint disease studies, HR-pQCT was a remarkable tool to assess bone erosion and joint space narrowing at the hand. This article gives an overview of this imaging technique.
许多影像学方法已被用于诊断和监测骨质疏松症（OP）、骨关节炎和炎症性风湿病。在过去的十年中，高分辨率外周定量计算机断层扫描（HR-pQCT）已被证明是一种精确的、非侵入性的技术，可用于临床研究中骨骼和关节疾病的研究。它允许在远端胫骨和桡骨上研究皮质骨和小梁骨的微结构，并进一步开发了机械性能的有限元分析等应用。因此，在病例对照和横断面研究中，微结构参数可独立于面积 BMD 区分骨折个体。此外，微观结构参数可预测绝经后妇女的骨折事件。在与骨脆性相关的代谢性疾病中，HR-pQCT 也可用于探索骨变化。在关节疾病研究中，HR-pQCT 是评估手部骨侵蚀和关节间隙变窄的重要工具。本文概述了这种影像学技术。
