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一名儿童的贫血与呼吸衰竭:会是特发性肺含铁血黄素沉着症吗?

Anaemia and respiratory failure in a child: can it be idiopathic pulmonary haemosiderosis?

作者信息

Ahmed Minhajuddin, Raj Dinesh, Kumar Ashwini, Kumar Abhay

机构信息

Department of Pediatrics, Holy Family Hospital, New Delhi, India.

出版信息

BMJ Case Rep. 2017 May 15;2017:bcr-2017-219431. doi: 10.1136/bcr-2017-219431.

Abstract

We present an 8-year-old male child admitted with cough and high-grade fever for 7 days and respiratory difficulty for 2 days. There was a history of blood transfusion at 2 years of age during a respiratory illness. The child was anaemic, tachycardic, tachypnoeic and hypoxic at presentation. Chest examination revealed equal air entry with fine crackles bilaterally. Blood reports were suggestive of anaemia (haemoglobin 6.5 g/dL), leucocytosis and high C reactive protein levels. Chest radiograph revealed bilateral air space opacities involving diffuse lung fields, right more than left. Relevant microbiological workup was negative. Based on the clinical scenario and investigations, a provisional diagnosis of pulmonary haemosiderosis was kept. The patient was started on intravenous pulse methylprednisolone. Fibre-optic bronchoscopy was done following recovery from the acute event. Bronchoalveolar lavage demonstrated a significant number of haemosiderin-laden macrophages confirming pulmonary haemosiderosis.

摘要

我们报告一名8岁男童,因咳嗽、高热7天,呼吸困难2天入院。该患儿2岁患呼吸系统疾病时曾有输血史。入院时患儿贫血、心动过速、呼吸急促且缺氧。胸部检查显示双侧呼吸音均等,可闻及细湿啰音。血液检查提示贫血(血红蛋白6.5g/dL)、白细胞增多及C反应蛋白水平升高。胸部X线片显示双侧肺野弥漫性气腔模糊,右侧较左侧明显。相关微生物学检查结果为阴性。根据临床表现及检查,初步诊断为肺含铁血黄素沉着症。患者开始接受静脉注射甲泼尼龙冲击治疗。急性症状缓解后进行了纤维支气管镜检查。支气管肺泡灌洗显示大量含铁血黄素巨噬细胞,确诊为肺含铁血黄素沉着症。

相似文献

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Idiopathic Pulmonary Hemosiderosis Presenting as Anemia, Failure to Thrive, and Jaundice in a Toddler.
Pediatr Emerg Care. 2016 Apr;32(4):237-9. doi: 10.1097/PEC.0000000000000501.

本文引用的文献

1
Idiopathic Pulmonary Hemosiderosis Presenting as Anemia, Failure to Thrive, and Jaundice in a Toddler.
Pediatr Emerg Care. 2016 Apr;32(4):237-9. doi: 10.1097/PEC.0000000000000501.
7
Screening for celiac disease in idiopathic pulmonary hemosiderosis.特发性肺含铁血黄素沉着症中乳糜泻的筛查
Gastroenterol Clin Biol. 2008 Aug-Sep;32(8-9):745-8. doi: 10.1016/j.gcb.2008.05.010. Epub 2008 Jul 7.

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