Dhingra Nalini, Zhao Xiaolan
Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.
Genes Dev. 2017 Apr 15;31(8):719-720. doi: 10.1101/gad.300491.117.
SUMO homeostasis is important for many cellular processes. In the current issue of , Liang and colleagues (pp. 802-815) demonstrate how a desumoylation enzyme is targeted to the nucleolus for removing SUMO from specific substrates and how curtailing sumoylation levels can regulate transcription in this nuclear compartment.
SUMO 稳态对许多细胞过程都很重要。在本期杂志中，梁及其同事（第 802 - 815 页）展示了一种去 SUMO 化酶如何被靶向运输到核仁以从特定底物上去除 SUMO，以及降低 SUMO 化水平如何调节这个核区室中的转录。
