靶向SUMO去除指南。
A guide for targeted SUMO removal.
作者信息
Dhingra Nalini, Zhao Xiaolan
机构信息
Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.
出版信息
Genes Dev. 2017 Apr 15;31(8):719-720. doi: 10.1101/gad.300491.117.
Abstract
SUMO homeostasis is important for many cellular processes. In the current issue of , Liang and colleagues (pp. 802-815) demonstrate how a desumoylation enzyme is targeted to the nucleolus for removing SUMO from specific substrates and how curtailing sumoylation levels can regulate transcription in this nuclear compartment.
摘要
SUMO 稳态对许多细胞过程都很重要。在本期杂志中，梁及其同事（第 802 - 815 页）展示了一种去 SUMO 化酶如何被靶向运输到核仁以从特定底物上去除 SUMO，以及降低 SUMO 化水平如何调节这个核区室中的转录。
Zotero 插件