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补中丹对正常受试者过度通气诱发的大脑中动脉二氧化碳反应性的影响：一项剂量依赖性研究。

The Effect of Chunghyul-Dan on Hyperventilation-Induced Carbon Dioxide Reactivity of the Middle Cerebral Artery in Normal Subjects: A Dose-Dependent Study.

作者信息

Jin Chul, Moon Sang-Kwan, Cho Seung-Yeon, Park Seong-Uk, Jung Woo-Sang, Park Jung-Mi, Ko Chang-Nam, Cho Ki-Ho, Kwon Seungwon

机构信息

Department of Cardiology and Neurology, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea.

出版信息

Evid Based Complement Alternat Med. 2017;2017:4567217. doi: 10.1155/2017/4567217. Epub 2017 Apr 20.

DOI:10.1155/2017/4567217
PMID:28512500
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5415863/
Abstract

. This study was conducted to show the prompt effect of chunghyul-dan (CHD) on cerebral hemodynamics in order to provide evidence for its use in stroke prevention. . Hyperventilation-induced CO reactivity of the middle cerebral artery was measured in 12 healthy male volunteers (mean age: 26.3 ± 1.1 years) using transcranial Doppler sonography. All subjects were examined before and for 3 hours after administration, with an interval of 1 week between measurements. . Compared to baseline, the CO reactivity of the middle cerebral artery increased significantly at 2 and 3 hours after the administration of CHD (600 mg and 1200 mg). The mean blood pressure and heart rate did not vary from the baseline values in all groups. . These data suggest that CHD administration (especially 600 mg) immediately improves cerebral blood flow.

摘要

本研究旨在展示川芎丹（CHD）对脑血流动力学的即时作用，以便为其在预防中风中的应用提供证据。使用经颅多普勒超声对12名健康男性志愿者（平均年龄：26.3±1.1岁）进行了大脑中动脉过度通气诱导的CO反应性测量。所有受试者在给药前及给药后3小时进行检查，测量间隔为1周。与基线相比，给予CHD（600mg和1200mg）后2小时和3小时，大脑中动脉的CO反应性显著增加。所有组的平均血压和心率与基线值相比没有变化。这些数据表明，给予CHD（尤其是600mg）可立即改善脑血流量。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99bb/5415863/713d86f988ad/ECAM2017-4567217.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99bb/5415863/e8a76f521e05/ECAM2017-4567217.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99bb/5415863/da6c67e44b83/ECAM2017-4567217.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99bb/5415863/1879a43a9ce9/ECAM2017-4567217.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99bb/5415863/713d86f988ad/ECAM2017-4567217.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99bb/5415863/e8a76f521e05/ECAM2017-4567217.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99bb/5415863/da6c67e44b83/ECAM2017-4567217.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99bb/5415863/1879a43a9ce9/ECAM2017-4567217.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99bb/5415863/713d86f988ad/ECAM2017-4567217.004.jpg

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本文引用的文献

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Cerebrovascular reserve may be a more accurate predictor of stroke than degree of ICA or MCA stenosis.脑血管储备可能是比颈内动脉（ICA）或大脑中动脉（MCA）狭窄程度更准确的中风预测指标。
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中律丹对小血管病患者中风复发的抑制作用：一项5年观察性研究。
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Lack of correlation between cerebral vasomotor reactivity and flow-mediated dilation in subjects without vascular disease.在无血管疾病的受试者中，脑血流反应性与血流介导的扩张之间缺乏相关性。
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