Vuletić Vladimira, Cengić Ljiljana, Basić Silvio, Sporis Davor, Rahelić Dario, Demarin Vida
University of Zagreb, Dubrava University Hospital, Department of Neurology, Zagreb, Croatia.
Coll Antropol. 2011 Mar;35(1):27-31.
The aim of our study was to assess cerebral vasoreactivity (CVR) in type 2 diabetes mellitus (DM2) and factors which may influence on it. According to previous studies, evaluating CVR in DM2 on the similar way, the results were dubious. For the evaluation CVR we used breath holding index (BHI) and transcranial Doppler ultrasound (TCD) in 50 patients with DM2 and 50 sex- and age-matched healthy controls. We observed epidemiologic and clinic data, other vascular risk factors and laboratory parameters. We found statistically significant difference in BHI between patients with DM2 (BHI = 0.69 +/- 0.31) and age- and sex-matched healthy controls (BHI = 1.33+/-0.28) (p < 0.05 ). Because of a significant correlation between BHI and age (p < 0.001) in healthy controls we made an adjustment of BHI for age before further analyses (BHIadj). In DM2 group we found a significant correlation between BHIadj and age (p = 0.0004), fasting glycemia (p = 0.04), and albuminuria (p = 0.04) (creatinine clearance in multivariate analysis (p = 0.007)). Our study has shown that CVR is impaired in DM2 patients and that it's severity was associated with age, fasting glycemia and renal function. Functional TCD is a very good screening method for detection and monitoring of cerebral microangiopathic changes in DM2 patients.
我们研究的目的是评估2型糖尿病（DM2）患者的脑血管反应性（CVR）及其可能的影响因素。根据以往的研究，以类似方式评估DM2患者的CVR，结果并不明确。为了评估CVR，我们对50例DM2患者和50例年龄及性别匹配的健康对照者使用了屏气指数（BHI）和经颅多普勒超声（TCD）。我们观察了流行病学和临床数据、其他血管危险因素及实验室参数。我们发现DM2患者（BHI = 0.69 +/- 0.31）与年龄及性别匹配的健康对照者（BHI = 1.33 +/- 0.28）之间的BHI存在统计学显著差异（p < 0.05）。由于健康对照者中BHI与年龄之间存在显著相关性（p < 0.001），因此在进一步分析之前我们对BHI进行了年龄校正（BHIadj）。在DM2组中，我们发现BHIadj与年龄（p = 0.0004）、空腹血糖（p = 0.04）及蛋白尿（p = 0.04）（多变量分析中的肌酐清除率，p = 0.007）之间存在显著相关性。我们的研究表明，DM2患者的CVR受损，其严重程度与年龄、空腹血糖及肾功能相关。功能性TCD是检测和监测DM2患者脑微血管病变的一种非常好的筛查方法。
