Cui Wenpeng, Min Xu, Xu Xiaohong, Du Bing, Luo Ping
Department of Nephrology, The Second Hospital of Jilin University, Changchun, Jilin 130041, China.
Department of Gynaecology and Obstetrics, The Second Hospital of Jilin University, Changchun, Jilin 130041, China.
J Diabetes Res. 2017;2017:3797802. doi: 10.1155/2017/3797802. Epub 2017 Apr 23.
Diabetic nephropathy (DN) is manifested as increased urinary protein level, decreased glomerular filtration rate, and final renal dysfunction. DN is the leading cause of end-stage renal disease worldwide and causes a huge societal healthcare burden. Since satisfied treatments are still limited, exploring new strategies for the treatment of this disease is urgently needed. Oxidative stress takes part in the initiation and development of DN. In addition, nuclear factor erythroid 2-related factor 2 (Nrf2) plays a key role in the cellular response to oxidative stress. Thus, activation of Nrf2 seems to be a new choice for the treatment of DN. In current review, we discussed and summarized the therapeutic effects of Nrf2 activation on DN from both basic and clinical studies.
糖尿病肾病（DN）表现为尿蛋白水平升高、肾小球滤过率降低，最终导致肾功能障碍。DN是全球终末期肾病的主要原因，给社会带来了巨大的医疗负担。由于令人满意的治疗方法仍然有限，迫切需要探索治疗该疾病的新策略。氧化应激参与了DN的发生和发展。此外，核因子红细胞2相关因子2（Nrf2）在细胞对氧化应激的反应中起关键作用。因此，激活Nrf2似乎是治疗DN的新选择。在当前的综述中，我们从基础研究和临床研究两方面讨论并总结了激活Nrf2对DN的治疗作用。
