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澳大利亚一家医院心力衰竭指南依从性审计:药剂师视角

An audit of adherence to heart failure guidelines in an Australian hospital: A pharmacist perspective.

作者信息

Khalil Viviane, Danninger Melanie, Wang Wei, Khalil Hanan

机构信息

Pharmacy Department, Frankston Hospital, Frankston, Australia.

Monash University, Parkville, Melbourne, Australia.

出版信息

J Eval Clin Pract. 2017 Dec;23(6):1195-1202. doi: 10.1111/jep.12760. Epub 2017 May 17.

Abstract

RATIONALE, AIMS, AND OBJECTIVES: The Australian National Heart Foundation Guidelines have been developed to guide clinicians on how to best manage chronic heart failure (CHF) patients according to the current best available evidence. The primary aim of this study is to evaluate the proportion of patients prescribed evidence-based therapy (EBT) for CHF on discharge at this Australian metropolitan hospital and factors affecting its prescribing. The secondary aims are to examine the proportion of patients prescribed EBT on discharge on cardiac wards compared to medical wards and to explore the role of the pharmacist in the management of these patients.

METHOD

A retrospective audit of patients' medical notes who were admitted consecutively for CHF management was conducted over 6 months to examine their management.

RESULTS

The results showed at discharge, a total of 52% of patients were discharged on angiotensin converting enzyme inhibitors/angiotensin receptor blockers, 49% were discharged on β-blockers, 15% were on Aldosterone receptor antagonists, 90% were discharged on diuretics, and 29% were discharged on Digoxin. The main determinants of prescribing EBT on discharge were the presence of prescribing contraindications and patients' comorbidities. Patients discharged from cardiac wards were more likely to be prescribed EBT than if discharged on medical wards. Furthermore, in the subset of the cohort who was reviewed by a pharmacist during admission, a higher percentage of patients were discharged on EBT compared with those who did not have a pharmaceutical input.

CONCLUSION

This study highlighted existing gaps between the National CHF Guidelines and clinical prescribing practice in this hospital. Patients who were discharged from cardiac wards were more likely to be prescribed medications concordant with the guidelines, and there is further opportunity for pharmacists to assist in closing gaps in prescribing practice by the promotion of adherence to these guidelines.

摘要

原理、目的和目标:澳大利亚国家心脏基金会制定了相关指南,旨在根据当前可得的最佳证据,指导临床医生如何最佳地管理慢性心力衰竭(CHF)患者。本研究的主要目的是评估这家澳大利亚大都市医院出院时接受基于证据的CHF治疗(EBT)的患者比例及其影响因素。次要目的是比较心脏科病房与内科病房出院时接受EBT治疗的患者比例,并探讨药剂师在这些患者管理中的作用。

方法

对连续入院接受CHF管理的患者病历进行了为期6个月的回顾性审核,以检查其治疗情况。

结果

结果显示,出院时,共有52%的患者出院时使用血管紧张素转换酶抑制剂/血管紧张素受体阻滞剂,49%的患者出院时使用β受体阻滞剂,15%的患者使用醛固酮受体拮抗剂,90%的患者出院时使用利尿剂,29%的患者出院时使用地高辛。出院时开具EBT的主要决定因素是存在开具禁忌证和患者的合并症。与内科病房出院的患者相比,心脏科病房出院的患者更有可能接受EBT治疗。此外,在入院期间由药剂师进行评估的队列子集中,与未接受药学干预的患者相比,出院时接受EBT治疗的患者比例更高。

结论

本研究突出了该医院国家CHF指南与临床处方实践之间存在的差距。心脏科病房出院的患者更有可能按照指南开具药物,药剂师通过促进对这些指南的遵守,在缩小处方实践差距方面还有进一步的机会。

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