a Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases , Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing , China.
Clin Exp Hypertens. 2017;39(4):366-370. doi: 10.1080/10641963.2016.1267190. Epub 2017 May 17.
Few studies had examined the role of ABO blood groups on CAD in hypertensive patients with different blood pressure (BP) controls.
A total of 2708 patients with primary hypertension (HTN) were consecutively enrolled and underwent coronary angiography (CAG) due to angina-like chest pain. The severity of coronary artery stenosis was assessed by Gensini score (GS). Patients were divided into two groups due to results of CAG: HTN with CAD (n = 2185) and HTN without CAD (n = 523). Poor BP control was defined as systolic BP (SBP) ≥ mean in the study. Multivariable regression analysis was used to determine the potential impact of ABO blood groups on risk of the presence and severity of CAD.
Compared to HTN without CAD group, the percentage of A blood group was statistically higher and O blood group was significantly lower in HTN with CAD group. Moreover, percentage of the angiography-proven CAD was higher in A blood group than that in non-A blood group (p < 0.05). After adjusting for confounding factors, A blood group was independently associated with CAD (odds ratio (OR): 1.422; 95% confidence interval (CI): 1.017-1.987; p = 0.039) and GS (β = 0.055, p = 0.046) in patients with poor BP control.
A blood group was an independent risk factor for the presence and severity of CAD in hypertensive patients with poor BP control.
鲜有研究探讨过不同血压控制水平的高血压患者中 ABO 血型在 CAD 中的作用。
共纳入 2708 例因胸痛类似心绞痛而接受冠状动脉造影（CAG）的原发性高血压（HTN）患者。采用 Gensini 评分（GS）评估冠状动脉狭窄严重程度。根据 CAG 结果将患者分为 HTN 合并 CAD 组（n=2185）和 HTN 不合并 CAD 组（n=523）。血压控制不佳定义为 SBP≥研究中的平均值。采用多变量回归分析来确定 ABO 血型对 CAD 存在和严重程度的潜在影响。
与 HTN 不合并 CAD 组相比，HTN 合并 CAD 组 A 型血比例明显较高，O 型血比例明显较低。此外，A 型血组的经造影证实的 CAD 比例高于非 A 型血组（p<0.05）。在校正混杂因素后，A 型血与 CAD（比值比（OR）：1.422；95%置信区间（CI）：1.017-1.987；p=0.039）和血压控制不佳患者的 GS（β=0.055，p=0.046）独立相关。
在血压控制不佳的高血压患者中，A 型血是 CAD 存在和严重程度的独立危险因素。
