Gong Ping, Luo Song-Hui, Li Xiao-Lin, Guo Yuan-Lin, Zhu Cheng-Gang, Xu Rui-Xia, Li Sha, Dong Qian, Liu Geng, Chen Juan, Zeng Rui-Xiang, Li Jian-Jun
Center for Dyslipidemia and Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, No 167 BeiLiShi Road, XiCheng District, Beijing 100037, China; Department of Cardiology, The Fifth Hospital of Wuhan & Affiliated Guangci Hospital of Wuhan University, Wuhan 430050, China.
Department of Cardiology, The Fifth Hospital of Wuhan & Affiliated Guangci Hospital of Wuhan University, Wuhan 430050, China.
Atherosclerosis. 2014 Dec;237(2):748-53. doi: 10.1016/j.atherosclerosis.2014.10.107. Epub 2014 Nov 4.
Although the study on the relationship between ABO blood groups and coronary atherosclerosis has a long history, few data is available regarding ABO to severity of coronary atherosclerosis in a large cohort study. Therefore, the present study aimed to investigate the relation of the ABO blood groups to the severity of coronary atherosclerosis assessed by Gensini score (GS) in a large Chinese cohort undergoing coronary angiography.
A total of 2919 consecutive patients undergoing coronary angiography were enrolled, and their baseline characteristics and ABO blood groups were collected. The GS was calculated as 1st tertile (0-10), 2nd tertile (11-36), 3rd tertile (>36) according to angiographic results. The relation of the ABO blood groups to GS was investigated.
The frequency of blood group A was significantly higher in the upper GS tertiles (24.4% vs. 28.2% vs. 29.5%, p = 0.032). Multivariable linear regression analysis revealed that blood group A was independently associated with GS (β = 0.043, p = 0.017). Likewise, multivariable logistic regression analysis showed that group A remained significantly associated with mid-high GS (OR = 1.44, 95% CI 1.16-1.80, p = 0.001), and the group O was showed as a protective factor (OR = 0.77, 95% CI = 0.65-0.92, p = 0.004).
In this large Chinese cohort study, the data indicated that there was an association between ABO blood groups and the severity of coronary atherosclerosis. Moreover, the blood group A was an independent risk factor for serious coronary atherosclerosis.
虽然关于ABO血型与冠状动脉粥样硬化之间关系的研究历史悠久，但在大型队列研究中，关于ABO血型与冠状动脉粥样硬化严重程度的数据却很少。因此，本研究旨在探讨在中国接受冠状动脉造影的大型队列中，ABO血型与通过Gensini评分（GS）评估的冠状动脉粥样硬化严重程度之间的关系。
共纳入2919例连续接受冠状动脉造影的患者，收集其基线特征和ABO血型。根据血管造影结果，将GS计算为第1三分位数（0 - 10）、第2三分位数（11 - 36）、第3三分位数（>36）。研究ABO血型与GS的关系。
在较高GS三分位数组中，A型血的频率显著更高（24.4%对28.2%对29.5%，p = 0.032）。多变量线性回归分析显示，A型血与GS独立相关（β = 0.043，p = 0.017）。同样，多变量逻辑回归分析表明，A型血仍与中高GS显著相关（OR = 1.44，95%CI 1.16 - 1.80，p = 0.001），而O型血显示为保护因素（OR = 0.77，95%CI = 0.65 - 0.92，p = 0.004）。
在这项大型中国队列研究中，数据表明ABO血型与冠状动脉粥样硬化严重程度之间存在关联。此外，A型血是严重冠状动脉粥样硬化的独立危险因素。
