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Effect of mid-follicular phase recombinant LH versus urinary HCG supplementation in poor ovarian responders undergoing IVF - a prospective double-blinded randomized study.卵泡中期重组促黄体生成素与尿人绒毛膜促性腺激素补充治疗对卵巢反应不良患者体外受精的影响——一项前瞻性双盲随机研究
Reprod Biomed Online. 2017 Mar;34(3):258-266. doi: 10.1016/j.rbmo.2016.11.014. Epub 2016 Dec 16.
2
Gonadotropin-releasing hormone agonist trigger is a better alternative than human chorionic gonadotropin in PCOS undergoing IVF cycles for an OHSS Free Clinic: A Randomized control trial.在接受体外受精周期的多囊卵巢综合征患者中，促性腺激素释放激素激动剂扳机方案比人绒毛膜促性腺激素更适合用于无卵巢过度刺激综合征的门诊：一项随机对照试验。
J Hum Reprod Sci. 2016 Jul-Sep;9(3):164-172. doi: 10.4103/0974-1208.192056.
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Early Short Stimulation Modified Natural Cycle IVF With GnRH Agonist Trigger and In Vitro Maturation in a Woman with Polycystic Ovary Syndrome: A Case Report.多囊卵巢综合征女性采用 GnRH 激动剂触发及体外成熟的早期短刺激改良自然周期 IVF：一例报告
J Obstet Gynaecol Can. 2016 May;38(5):465-9. doi: 10.1016/j.jogc.2016.02.002. Epub 2016 Apr 14.
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Hum Reprod. 2016 Jul;31(7):1383-6. doi: 10.1093/humrep/dew109. Epub 2016 May 9.
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Cochrane Database Syst Rev. 2016 Apr 23;4(4):CD003719. doi: 10.1002/14651858.CD003719.pub4.
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Mol Cell Endocrinol. 2016 Feb 15;422:103-114. doi: 10.1016/j.mce.2015.12.008. Epub 2015 Dec 12.
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J Ovarian Res. 2015 Aug 21;8:60. doi: 10.1186/s13048-015-0187-6.
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Clinical outcomes from mature oocytes derived from preovulatory and antral follicles: reflections on follicle physiology and oocyte competence.来自排卵前卵泡和窦卵泡的成熟卵母细胞的临床结局：对卵泡生理学和卵母细胞能力的思考
J Assist Reprod Genet. 2015 Feb;32(2):255-61. doi: 10.1007/s10815-014-0386-x. Epub 2014 Dec 2.
9
Gonadotropin-releasing hormone agonist versus HCG for oocyte triggering in antagonist-assisted reproductive technology.在拮抗剂辅助生殖技术中，促性腺激素释放激素激动剂与绒毛膜促性腺激素用于卵母细胞触发的比较
Cochrane Database Syst Rev. 2014 Oct 31;2014(10):CD008046. doi: 10.1002/14651858.CD008046.pub4.
10
Co-administration of GnRH-agonist and hCG for final oocyte maturation (double trigger) in patients with low number of oocytes retrieved per number of preovulatory follicles--a preliminary report.在每个排卵前卵泡中获取的卵母细胞数量较少的患者中，联合使用促性腺激素释放激素激动剂（GnRH-agonist）和人绒毛膜促性腺激素（hCG）进行最终卵母细胞成熟（双重触发）——初步报告。
J Ovarian Res. 2014 Aug 2;7:77. doi: 10.1186/1757-2215-7-77.

辅助生殖技术中的人绒毛膜促性腺激素触发：一个进化概念。

hCG Triggering in ART: An Evolutionary Concept.

作者信息

Hershko Klement Anat, Shulman Adrian

机构信息

Department of Obstetrics and Gynecology, Meir Medical Center, Kfar Saba 4428164, Israel.

The Sackler School of Medicine, Tel Aviv University, Tel Aviv-Yafo 6997801, Israel.

出版信息

Int J Mol Sci. 2017 May 17;18(5):1075. doi: 10.3390/ijms18051075.

DOI:10.3390/ijms18051075
PMID:28513550
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5454984/
Abstract

Human chorionic gonadotropin (hCG) is no longer a single, omnipotent ovulation triggering option. Gonadotropin releasing hormone (GnRH) agonist, initially presented as a substitute for hCG, has led to a new era of administering GnRH agonist followed by hCG triggering. According to this new concept, GnRH agonist enables successful ovum maturation, while hCG supports the luteal phase and pregnancy until placental shift.

摘要

人绒毛膜促性腺激素（hCG）不再是唯一的、万能的促排卵触发选择。促性腺激素释放激素（GnRH）激动剂最初作为hCG的替代品出现，开启了先使用GnRH激动剂然后进行hCG触发的新时代。根据这一新概念，GnRH激动剂可使卵子成功成熟，而hCG则在胎盘功能转换之前支持黄体期和维持妊娠。