二乙基二硫代氨基甲酸钠（依木硫醇）对断奶仔猪淋巴细胞功能和生长的影响。

Influence of sodium diethyldithiocarbamate (Imuthiol) on lymphocyte function and growth in weanling pigs.

作者信息

Flaming K P, Thaler R C, Blecha F, Nelssen J L

机构信息

Department of Anatomy and Physiology, College of Veterinary Medicine, Kansas State University, Manhattan 66506.

出版信息

Comp Immunol Microbiol Infect Dis. 1988;11(3-4):181-7. doi: 10.1016/0147-9571(88)90036-7.

DOI:10.1016/0147-9571(88)90036-7

PMID:2851408

Abstract

Mitogen-stimulated lymphocyte proliferation, delayed-type hypersensitivity (DTH) reactions, interleukin-2 (IL-2) production, and growth performance were evaluated in 3-week-old pigs treated with imuthiol. Lymphocyte proliferative responses to Con A and PWM were reduced (P less than 0.05) in pigs treated with imuthiol at 25 mg/kg; PHA proliferative responses were not influenced by imuthiol treatment. Imuthiol at 2.5 mg/kg lowered IL-2 production when compared to saline-treated controls. Delayed-type hypersensitivity responses to PHA were higher in 25 mg/kg imuthiol-treated pigs; however, 2.5 mg/kg imuthiol-treated pigs had lower DHT reactions. Imuthiol at 2.5 mg/kg and 25 mg/kg reduced (P less than 0.05) average daily feed intake. These data suggest that in vivo imuthiol treatment in pigs lowers lymphocyte proliferative responses, IL-2 production, and growth performance.

摘要

对用免疫硫醇处理的3周龄仔猪评估了丝裂原刺激的淋巴细胞增殖、迟发型超敏反应（DTH）、白细胞介素-2（IL-2）产生和生长性能。用25mg/kg免疫硫醇处理的仔猪对刀豆蛋白A和美洲商陆有丝分裂原的淋巴细胞增殖反应降低（P<0.05）；免疫硫醇处理对PHA增殖反应无影响。与生理盐水处理的对照组相比，2.5mg/kg的免疫硫醇降低了IL-2的产生。对PHA的迟发型超敏反应在25mg/kg免疫硫醇处理的仔猪中较高；然而，2.5mg/kg免疫硫醇处理的仔猪DHT反应较低。2.5mg/kg和25mg/kg的免疫硫醇降低了（P<0.05）平均日采食量。这些数据表明，猪体内免疫硫醇处理会降低淋巴细胞增殖反应、IL-2产生和生长性能。