Koptopoulos G, Papanastasopoulou M, Papadopoulos O, Ludwig H
Department of Infectious and Parasitic Diseases, Aristotelian University, Thessaloniki, Greece.
Comp Immunol Microbiol Infect Dis. 1988;11(3-4):199-205. doi: 10.1016/0147-9571(88)90038-0.
Previous preliminary studies had shown that caprine herpesvirus (BHV-6) infections exist in many countries where goats play an economical role. The extensive serum survey made in Greece reveals that the virus must be widespread because more than 50% of the goats have antibodies. The bucks were found to have a higher evidence of infections than the female goats. The kids possessing maternal antibodies became seronegative at the age of 4 months and new antibodies appeared at the age of 7-8 months. Observations in 2 closed goat herds showed that the virus does not spread during the mating and lactating period. Neutralization titres increased or new infections in seronegative animals occurred after the summer when breeding took place. The virus is present in a latent state and recurrent infections are assumed to occur. In spite of that all our efforts to isolate the virus were unsuccessful, even after experimental immunosuppression.
先前的初步研究表明，在许多山羊具有经济价值的国家都存在山羊疱疹病毒（BHV - 6）感染。在希腊进行的广泛血清调查显示，该病毒一定广泛存在，因为超过50%的山羊有抗体。发现雄性山羊的感染证据比雌性山羊更多。拥有母源抗体的幼崽在4个月大时血清学转为阴性，7 - 8个月大时出现新的抗体。在2个封闭山羊群中的观察表明，该病毒在交配和哺乳期不会传播。夏季繁殖后，血清阴性动物的中和抗体滴度升高或出现新的感染。病毒以潜伏状态存在，推测会发生复发性感染。尽管我们竭尽全力分离病毒，但即使经过实验性免疫抑制，仍未成功。
