Chen Yin-Ling, Qiao Yong-Chao, Song Xin-Nan, Ling Wei, Zhao Hai-Lu, Zhang Xiao-Xi
Center of Diabetic Systems Medicine, Guangxi Key Laboratory of Excellence, Guilin Medical University, Guilin Department of Immunology, Xiangya School of Medicine, Central South University, Changsha, Hunan Department of Immunology, Faculty of Basic Medicine, Guilin Medical University, Guilin, China.
Medicine (Baltimore). 2017 May;96(20):e6915. doi: 10.1097/MD.0000000000006915.
Latent autoimmune diabetes in adults (LADA) refers to an autoimmune disorder characterized with detectable islets antibodies in the early diagnosis and increased autoimmune beta-cell failure progression. Notably, this kind of diabetes seems to be confused with other phenotypic diabetes.
A young woman suffered an emotional exhaustion-induced LADA, showing asthenia, polydipsia, polyuria, and visible weight loss. The patient emotionally ended a 14-year romantic relationship, leading to the emotional flooding.
The data from physical examination and laboratory tests exhibited as follows: glutamic acid decarboxylase antibody (GADA) = 63.83 U/mL, the fasting blood glucose (FBG) = 13.3 mmol/L, and glycated haemoglobin (HbA1c) = 10.9%. According to levels of GADA, the patient was diagnosed as LADA.
The patient was clinically treated with insulin for 3-month. Then, running, diet-control, and emotional treatment were combined, such as the patient started a new relationship.
An emotional recovery initiated from a new romantic relationship and a baby, showing normal levels of GAD65 (27.007 IU/mL) and FBG (5.46) mmol/L.
The emotional exhaustion might play a significant role in induction of LADA. It is important that individuals should maintain optimism, cheer, and a positive attitude.
成人隐匿性自身免疫性糖尿病（LADA）是一种自身免疫性疾病，其特征为早期诊断时可检测到胰岛抗体，且自身免疫性β细胞功能衰竭进展加快。值得注意的是，这种糖尿病似乎容易与其他表型糖尿病相混淆。
一名年轻女性因情绪衰竭诱发了LADA，出现乏力、多饮、多尿及明显体重减轻。患者因情绪原因结束了一段14年的恋爱关系，导致情绪崩溃。
体格检查和实验室检查数据如下：谷氨酸脱羧酶抗体（GADA）=63.83 U/mL，空腹血糖（FBG）=13.3 mmol/L，糖化血红蛋白（HbA1c）=10.9%。根据GADA水平，该患者被诊断为LADA。
患者接受了3个月的胰岛素临床治疗。随后，结合跑步、饮食控制和情绪治疗，比如患者开始了一段新恋情。
一段新恋情和一个孩子使患者情绪恢复，GAD65（27.007 IU/mL）和FBG（5.46）mmol/L水平恢复正常。
情绪衰竭可能在LADA的诱发中起重要作用。个人保持乐观、愉悦和积极的态度很重要。
