一种名为成人隐匿性自身免疫性糖尿病（LADA）的疾病——基本特征与争议的最新进展
A form of Autoimmune Diabetes in Adults Named LADA - An Update on Essential Features and Controversies.
作者信息
Grill Valdemar, Åsvold Bjørn O
机构信息
Department of Clinical and Molecular Medicine, NTNU, Norwegian University of Science and Technology, NO-7491 Trondheim, Norway.
K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, NO-7491 Trondheim, Norway.
出版信息
Curr Diabetes Rev. 2019;15(3):172-173. doi: 10.2174/1573399814666180716152342.
Latent Autoimmune Diabetes in the Adult, LADA has been investigated less than "classical" type 1 and type 2 diabetes and the criteria for and the relevance of a LADA diagnosis has been challenged. Despite the absence of a genetic background that is exclusive to LADA, this form of diabetes displays phenotypic characteristics that distinguish it from other forms of diabetes. LADA is heterogeneous in terms of the impact of autoimmunity and lifestyle factors, something that poses problems as to therapy and follow-up perhaps particularly in those with marginal positivity. Yet, there appears to be clear clinical utility in classifying individuals as LADA.
成人隐匿性自身免疫性糖尿病（LADA）的研究比“经典”1型和2型糖尿病少，LADA诊断的标准及其相关性也受到了质疑。尽管LADA没有独特的遗传背景，但这种糖尿病形式表现出的表型特征使其有别于其他糖尿病形式。LADA在自身免疫和生活方式因素的影响方面具有异质性，这在治疗和随访方面带来了问题，尤其是对那些弱阳性个体而言。然而，将个体归类为LADA似乎具有明确的临床实用性。
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