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[依托考昔治疗老年骨关节炎的可行性证据]

[Evidence of feasibility etoricoxib therapy in osteoarthritis in elderly patients].

作者信息

Sivordova L E, Zavodovsky B V, Polyakova J V, Akhverdyan Y R

机构信息

Research Institute of clinical and experimental rheumatology, Volgograd, 400138, Russian Federation;

出版信息

Adv Gerontol. 2016;29(2):286-290.

PMID:28514547
Abstract

The article presents the results of a study of clinical efficacy in the treatment of etorikoxib pain in patients with osteoarthritis of the knee and hip joints in elderly patients. The study involved 296 patients with gonarthrosis and coxarthrosis. It is shown that etoricoxib effectively relieves pain, has an advantage over other NSAIDs speed and severity of the analgesic and anti-inflammatory effect, positive impact on laboratory signs of inflammation, demonstrated good tolerability and a low incidence of side effects, does not require discontinuation of therapy.

摘要

本文介绍了一项针对老年患者膝关节和髋关节骨关节炎使用依托考昔治疗疼痛的临床疗效研究结果。该研究纳入了296例膝关节炎和髋关节炎患者。结果表明,依托考昔能有效缓解疼痛,在镇痛和抗炎作用的速度及强度方面优于其他非甾体抗炎药,对炎症实验室指标有积极影响,耐受性良好且副作用发生率低,无需中断治疗。

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[Evidence of feasibility etoricoxib therapy in osteoarthritis in elderly patients].[依托考昔治疗老年骨关节炎的可行性证据]
Adv Gerontol. 2016;29(2):286-290.
2
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引用本文的文献

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Effect of Etoricoxib on miR-214 and inflammatory reaction in knee osteoarthritis patients.依托考昔对膝骨关节炎患者miR-214及炎症反应的影响
Am J Transl Res. 2021 Aug 15;13(8):9586-9592. eCollection 2021.
2
STAT3 speeds up progression of osteoarthritis through NF-κB signaling pathway.信号转导和转录激活因子3(STAT3)通过核因子κB(NF-κB)信号通路加速骨关节炎的进展。
Exp Ther Med. 2020 Jan;19(1):722-728. doi: 10.3892/etm.2019.8268. Epub 2019 Dec 2.