大小无关紧要：较短的抗体环可以渗透 HIV 的Env 顶点防御。
Size Doesn't Matter: Shorter Antibody Loops Can Infiltrate HIV's Env Apex Defenses.
机构信息
Centre for HIV and STIs, National Institute for Communicable Diseases of the National Health Laboratory Service (NHLS), Johannesburg 2131, South Africa; Faculty of Health Sciences, University of the Witwatersrand, Johannesburg 2050, South Africa.
Centre for HIV and STIs, National Institute for Communicable Diseases of the National Health Laboratory Service (NHLS), Johannesburg 2131, South Africa; Faculty of Health Sciences, University of the Witwatersrand, Johannesburg 2050, South Africa; Centre for the AIDS Programme of Research in South Africa (CAPRISA), University of KwaZulu Natal, Durban 4013, South Africa.
出版信息
Immunity. 2017 May 16;46(5):762-764. doi: 10.1016/j.immuni.2017.04.012.
An HIV vaccine that elicits broadly neutralizing antibodies, which often have unusual structural features, has not yet been developed. In Immunity this month, Cale et al., 2017 describe how a new mode of binding allows a conventional antibody to infiltrate HIV's armor.
一种能引发广泛中和抗体的 HIV 疫苗尚未被开发出来，而这些中和抗体通常具有不寻常的结构特征。在本月的《免疫》杂志上，Cale 等人描述了一种新的结合模式如何使传统抗体渗透到 HIV 的盔甲中。
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