Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, 1105 AZ Amsterdam, the Netherlands.
Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, 1105 AZ Amsterdam, the Netherlands; Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10021, USA.
Immunity. 2018 Jul 17;49(1):14-15. doi: 10.1016/j.immuni.2018.07.003.
The HIV-1 fusion peptide is a target for broadly neutralizing antibodies. In a recent issue of Nature Medicine, Xu et al. (2018) provide proof-of-concept that vaccination with fusion peptide followed by vaccination with an envelope glycoprotein trimer can induce antibodies in animal models that neutralize diverse HIV-1 viruses.
HIV-1 融合肽是广泛中和抗体的靶标。在最近一期的《自然医学》杂志上，Xu 等人（2018 年）提供了概念验证，即融合肽疫苗接种后再接种包膜糖蛋白三聚体疫苗，可以在动物模型中诱导中和多种 HIV-1 病毒的抗体。
