Colombel J F, Hällgren R, Venge P, Mesnard B, Rambaud J C
Department of Gastroenterology, Lille, France.
Gut. 1988 Dec;29(12):1656-60. doi: 10.1136/gut.29.12.1656.
Excessive ethanol intake may affect the intestinal mucosa functionally and morphologically. The ethanol effect could partly be the result of inflammatory mechanisms, possibly reflected by an enhanced local granulocyte turnover. This study investigated habitual alcoholics by segmental perfusion of the jejunum and analysed the perfusion fluid content of granulocyte granule constituents. The mean jejunal secretion rate of myeloperoxidase (MPO), a neutrophil granule constituent, was 152 (26) (SE) ng/min/40 cm jejunal segment in the controls (n = 16). The MPO secretion rate in non-cirrhotic habitual alcoholics (n = 7) was on average 450 (103) ng/min and significantly increased compared with controls (p less than 0.001). In contrast alcoholics with cirrhosis (n = 6) had normal MPO secretion rate. The mean secretion rate of eosinophil cationic protein (ECP), an eosinophil granule constituent, was in the controls 77 (15) ng/min/40 cm jejunal segment. Corresponding values in non-cirrhotic and cirrhotic alcoholics were 141 (38) and 130 (93) ng/min, respectively (ns). The data suggest an enhanced neutrophil granulocyte turnover in the jejunum in alcoholics, possibly contributing to the ethanol induced affection of the small bowel. The lack of increased neutrophil activity in cirrhotic alcoholics may reflect a role of the liver for granulocyte activity.
过量摄入乙醇可能在功能和形态上影响肠黏膜。乙醇的作用可能部分是炎症机制的结果，这可能通过局部粒细胞更新增强来体现。本研究通过空肠节段灌注对习惯性酗酒者进行调查，并分析灌注液中粒细胞颗粒成分的含量。对照组（n = 16）中，中性粒细胞颗粒成分髓过氧化物酶（MPO）的空肠平均分泌率为152（26）（标准误）纳克/分钟/40厘米空肠节段。非肝硬化习惯性酗酒者（n = 7）的MPO分泌率平均为450（103）纳克/分钟，与对照组相比显著增加（p < 0.001）。相比之下，肝硬化酗酒者（n = 6）的MPO分泌率正常。嗜酸性粒细胞颗粒成分嗜酸性粒细胞阳离子蛋白（ECP）的平均分泌率在对照组中为77（15）纳克/分钟/40厘米空肠节段。非肝硬化和肝硬化酗酒者的相应值分别为141（38）和130（93）纳克/分钟（无显著性差异）。数据表明酗酒者空肠中的中性粒细胞更新增强，这可能是乙醇诱导小肠病变的原因之一。肝硬化酗酒者中性粒细胞活性未增加可能反映了肝脏对粒细胞活性的作用。
