Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital.
Department of Otolaryngology-Head and Neck Surgery, Hokkaido University Graduate School of Medicine.
Magn Reson Med Sci. 2018 Jan 10;17(1):21-27. doi: 10.2463/mrms.mp.2016-0136. Epub 2017 May 18.
To evaluate the diagnostic power of hybrid intravoxel incoherent motion (IVIM)-diffusion kurtosis imaging (DKI) model parameters in pretreatment for the prediction of future distant metastasis in head and neck squamous cell carcinoma (HNSCC) patients.
We retrospectively evaluated 49 HNSCC patients who underwent curative chemoradiation therapy. Diffusion-weighted image (DWI) acquired by single-shot spin-echo echo-planar imaging with 12 b-values (0-2000) was performed in all patients before any treatment. We calculated the IVIM-DKI parameters and the conventional apparent diffusion coefficient (ADC) in the ROI placed on the primary lesion. The presence of future distant metastasis was determined by histological findings or clinical follow-up.
A univariate analysis revealed significant differences between the patients with distant metastasis and those without in slow diffusion coefficient (D) and kurtosis value (K). Highest diagnostic accuracy was obtained by the D value. In addition, a multivariate analysis revealed that the D value was an independent predictor of future distant metastasis.
The D and K values obtained by this hybrid IVIM-DKI model can be one of the diagnostic tools for the prediction of future distant metastasis in HNSCC patients.
评估杂合型体素内不相干运动（IVIM）-扩散峰度成像（DKI）模型参数在头颈部鳞状细胞癌（HNSCC）患者治疗前对预测未来远处转移的诊断能力。
我们回顾性评估了 49 例接受根治性放化疗的 HNSCC 患者。所有患者在任何治疗前均行单次激发自旋回波平面成像（EPI）采集的扩散加权成像（DWI），共 12 个 b 值（0-2000）。我们在原发性病变的 ROI 上计算 IVIM-DKI 参数和常规表观扩散系数（ADC）。通过组织学发现或临床随访确定是否存在未来远处转移。
单因素分析显示，有远处转移和无远处转移的患者在慢扩散系数（D）和峰度值（K）方面存在显著差异。D 值的诊断准确性最高。此外，多因素分析显示 D 值是预测 HNSCC 患者未来远处转移的独立预测因子。
该杂合 IVIM-DKI 模型获得的 D 值和 K 值可作为预测 HNSCC 患者未来远处转移的一种诊断工具。
