Sulistyo Hidayat, Kurniawan Dhadhang Wahyu, Rujito Lantip
Department of Pathological Anatomy, Faculty of Medicine, Jenderal Soedirman University, Indonesia.
Department of Pharmaceutices, Faculty of Health Sciences, Jenderal Soedirman University, Indonesia.
Res Pharm Sci. 2017 Apr;12(2):99-106. doi: 10.4103/1735-5362.202448.
Transfusion in the treatment of thalassemia gives rise to iron deposits in many organs. Since there are many obstacles in the use of deferoxamin (DFO) as an iron chelating agent, it is important to find another alternative therapy that can act as iron chelation. The study aims to compare the histopathological pictures of the heart and spleen in iron-induced rats after administration of DFO and nanoparticles of green tea extract. The research used experimental research design with a post-test only control group. Experimental nano green teas were divided into four treatment groups; no diet, DFO supplementation, nano green tea supplementation, and a combination of both DFO and green tea. Ferritin and glutathione peroxides were used as biochemical parameters, and histopathological pictures of the heart and spleen were recorded. The study showed that there was significant improvement in the rats receiving DFO and nanoparticles of green tea compared with the rats in the no diet group. The study also reported that nano green tea has an effect comparable to DFO.
输血治疗地中海贫血会导致铁在许多器官中沉积。由于使用去铁胺（DFO）作为铁螯合剂存在诸多障碍，因此寻找另一种可作为铁螯合的替代疗法很重要。本研究旨在比较给予DFO和绿茶提取物纳米颗粒后，铁诱导大鼠心脏和脾脏的组织病理学图像。该研究采用仅设后测对照组的实验研究设计。实验性纳米绿茶分为四个治疗组：无饮食组、补充DFO组、补充纳米绿茶组以及DFO和绿茶联合组。使用铁蛋白和谷胱甘肽过氧化物作为生化参数，并记录心脏和脾脏的组织病理学图像。研究表明，与无饮食组大鼠相比，接受DFO和绿茶提取物纳米颗粒的大鼠有显著改善。该研究还报告称，纳米绿茶具有与DFO相当的效果。
