循环微RNA在肝脏疾病中的作用。
Role of circulating microRNAs in liver diseases.
作者信息
Loosen Sven H, Schueller Florian, Trautwein Christian, Roy Sanchari, Roderburg Christoph
机构信息
Sven H Loosen, Florian Schueller, Christian Trautwein, Sanchari Roy, Christoph Roderburg, Department of Medicine III, University Hospital RWTH Aachen, 52074 Aachen, Germany.
出版信息
World J Hepatol. 2017 Apr 28;9(12):586-594. doi: 10.4254/wjh.v9.i12.586.
Abstract
MicroRNAs (miRNAs) are small RNAs regulate gene expression by inhibiting the turnover of their target mRNAs. In the last years, it became apparent that miRNAs are released into the circulation and circulating miRNAs emerged as a new class of biomarkers for various diseases. In this review we summarize available data on the role of circulating miRNAs in the context of acute and chronic liver diseases including hepatocellular and cholangiocellular carcinoma. Data from animal models are compared to human data and current challenges in the field of miRNAs research are discussed.
摘要
微小RNA（miRNA）是一类小RNA，通过抑制其靶mRNA的周转来调节基因表达。在过去几年中，越来越明显的是，miRNA会释放到循环系统中，循环miRNA已成为各种疾病的一类新型生物标志物。在本综述中，我们总结了关于循环miRNA在急性和慢性肝病（包括肝细胞癌和胆管细胞癌）中的作用的现有数据。将动物模型的数据与人类数据进行了比较，并讨论了miRNA研究领域当前面临的挑战。
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