Ziesenitz Victoria C, Zutter Andreas, Erb Thomas O, van den Anker Johannes N
Division of Paediatric Pharmacology and Pharmacometrics, University of Basel Children's Hospital, Spitalstrasse 33, 4056, Basel, Switzerland.
Department of Paediatric Cardiology, University Children's Hospital, Heidelberg, Germany.
Paediatr Drugs. 2017 Aug;19(4):277-290. doi: 10.1007/s40272-017-0235-3.
Ibuprofen is a non-steroidal anti-inflammatory drug frequently administered to children of various ages for relief of fever and pain and is approved as an over-the-counter medication in many countries worldwide. Although there are extensive data on its efficacy and safety in children and adults, there are divergent dosing recommendations for analgesia and treatment of fever in infants, especially in the age group between 3 and 6 months of age. In this article, we have assessed the safety and efficacy of ibuprofen use in infants in an attempt to find the optimal method of pain and fever management in this specific age group. Based on the current evidence, short-term use of ibuprofen is considered safe in infants older than 3 months of age having a body weight above 5-6 kg when special attention is given to the hydration of the patient. Ibuprofen should be prescribed based on body weight using a dose of 5-10 mg/kg. This dose can be administered 3-4 times a day resulting in a maximum total daily dose of 30-40 mg/kg. The rectal route has been shown to be less reliable because of erratic absorption, especially in young infants. Since most efficacy and safety data have been derived from trials in infants with fever, future studies should focus on the efficacy of ibuprofen in young infants with pain.
布洛芬是一种非甾体抗炎药，常用于不同年龄段儿童以缓解发热和疼痛，在全球许多国家被批准为非处方药。尽管有大量关于其在儿童和成人中的疗效和安全性的数据，但对于婴儿尤其是3至6个月龄婴儿的镇痛和发热治疗，给药建议存在分歧。在本文中，我们评估了布洛芬在婴儿中的安全性和疗效，试图找到针对这一特定年龄组疼痛和发热管理的最佳方法。根据目前的证据，当特别关注患者的水合作用时，3个月龄以上、体重超过5至6千克的婴儿短期使用布洛芬被认为是安全的。布洛芬应根据体重按5至10毫克/千克的剂量开具。该剂量可每天给药3至4次，导致最大每日总剂量为30至40毫克/千克。由于吸收不稳定，直肠给药途径已被证明不太可靠，尤其是在小婴儿中。由于大多数疗效和安全性数据来自发热婴儿的试验，未来的研究应侧重于布洛芬在疼痛小婴儿中的疗效。
