Newman Lisa A
Oncology (Williston Park). 2017 May 15;31(5):415-20.
Treatment of early-stage invasive breast cancer with breast-conserving surgery plus radiation therapy (RT) yields overall survival outcomes equivalent to those achieved with mastectomy. Further, breast-conserving surgery is endorsed by the National Comprehensive Cancer Network as being supported by the highest-level, category 1 evidence. Advances in pathologic evaluation, management of multiple tumors, oncoplastic lumpectomy techniques, neoadjuvant chemotherapy, and hypofractionated RT can expand the pool of patients eligible for breast-conserving surgery. Selected patients (for example, patients older than 70 years of age with hormone receptor-positive T1 tumors who are willing to commit to receiving adjuvant endocrine therapy) may be able to forgo RT completely. This article will detail current management approaches to achieving breast conservation in patients with invasive breast cancer, including cases of bulky tumors and/or multiple tumors.
早期浸润性乳腺癌采用保乳手术加放射治疗（RT）的总体生存结果与乳房切除术相当。此外，保乳手术得到了美国国立综合癌症网络的认可，有最高级别（1类）证据支持。病理评估、多原发肿瘤管理、肿瘤整形保乳技术、新辅助化疗和大分割放疗方面的进展可以扩大适合保乳手术的患者群体。部分患者（例如，年龄大于70岁、激素受体阳性T1肿瘤且愿意接受辅助内分泌治疗的患者）可能能够完全不进行放疗。本文将详细介绍浸润性乳腺癌患者实现保乳的当前管理方法，包括肿块较大和/或多原发肿瘤的情况。
