Jiang R, Fleck A, Schaly B, Charland P, Zhan L, Alliet K, Rachakonda R, Osei E
Grand River Regional Cancer Centre.
Department of Physics and Astronomy, University of Waterloo.
Med Phys. 2012 Jul;39(7Part4):4637. doi: 10.1118/1.4740174.
Volumetric modulated arc therapy (VMAT) has recently been used to improve the dose distribution and efficiency of treatment delivery over the standard intensity-modulated radiotherapy (IMRT) technique. This study compares the dosimetry between RapidArc plan and standard IMRT plan for head and neck cancer. Three head and neck patients treated clinically with sliding window intensity-modulated radiotherapy (IMRT) technique at Grand River Regional Cancer Center were selected randomly and re-planned using RapidArc technique with 6 MV photon beams generated by a Varian 21EX linac with 120-leaf multileaf collimator. Three dose prescriptions were used to deliver 70 Gy, 63 Gy and 58.1 Gy to the regions of the primary tumors, intermediate-risk nodes and low-risk nodal level, respectively, in 35 fractions. Dosimetric comparison based on the dose-volume histogram, target coverage, organ at risk (OAR) dose sparing were studied between the RapidArc plan and IMRT plan. RapidArc technique from Varian Medical Systems showed superior target coverage, better OAR sparing, fewer monitor units per fraction with less treatment time over IMRT technique for head and neck cancers. The average homogeneity index, defined as the difference between the percentage dose covering 5% and 95% of the PTV, is 9.5 for RapidArc plan and 10.5 for IMRT plan. All RapidArc plans met the dose objectives for the primary OAR: spinal cord, brainstem, brain etc. Both parotid mean dose and D50% are lower for RapidArc plan than those of the IMRT plan. The technique is currently being used clinically at our cancer center.
容积调强弧形放疗(VMAT)最近已被用于改善剂量分布,并提高与标准调强放疗(IMRT)技术相比的治疗实施效率。本研究比较了头颈部癌的容积调强弧形放疗(RapidArc)计划和标准调强放疗(IMRT)计划的剂量学。随机选择了三名在大河地区癌症中心接受滑动窗口调强放疗(IMRT)技术临床治疗的头颈部患者,并使用Varian 21EX直线加速器和120叶多叶准直器产生的6 MV光子束,采用容积调强弧形放疗(RapidArc)技术重新计划。分别使用三种剂量处方,在35次分割中向原发肿瘤区域、中危淋巴结和低危淋巴结水平分别给予70 Gy、63 Gy和58.1 Gy。研究了容积调强弧形放疗(RapidArc)计划和调强放疗(IMRT)计划之间基于剂量体积直方图、靶区覆盖、危及器官(OAR)剂量 sparing的剂量学比较。Varian医疗系统公司的容积调强弧形放疗(RapidArc)技术在头颈部癌方面显示出比调强放疗(IMRT)技术更好的靶区覆盖、更好的危及器官 sparing、每次分割的监测单位更少且治疗时间更短。定义为覆盖计划靶体积(PTV)5%和95%的剂量百分比之差的平均均匀性指数,容积调强弧形放疗(RapidArc)计划为9.5,调强放疗(IMRT)计划为10.5。所有容积调强弧形放疗(RapidArc)计划均达到了主要危及器官(OAR)的剂量目标:脊髓、脑干、脑等。容积调强弧形放疗(RapidArc)计划的双侧腮腺平均剂量和D50%均低于调强放疗(IMRT)计划。该技术目前正在我们癌症中心临床应用。