三金属氮化物包合物富勒烯羧基-GdN@C：一种用于对抗氧化应激和解决炎症的新型治疗诊断一体化试剂。
Trimetallic Nitride Endohedral Fullerenes Carboxyl-GdN@C: A New Theranostic Agent for Combating Oxidative Stress and Resolving Inflammation.
机构信息
Department of Chemistry, Virginia Polytechnic Institute and State University , Blacksburg, Virginia 24061, United States.
Department of Orthopaedic Surgery, University of Virginia , Charlottesville, Virginia 22903, United States.
出版信息
ACS Appl Mater Interfaces. 2017 May 31;9(21):17681-17687. doi: 10.1021/acsami.7b04718. Epub 2017 May 19.
Abstract
Antioxidative and anti-inflammatory effects of trimetallic nitride endohedral fullerenes carboxyl-GdN@C, a newly developed magnetic resonance imaging (MRI) contrast agent, were investigated. All hydrochalarone and carboxyl-functionalized fullerenes showed effective radical (hydroxyl and superoxide anion) scavenging, whereas the carboxyl-GdN@C more efficiently attenuated lipopolysaccharide (LPS) induced oxidative stress in macrophages. Carboxyl-GdN@C also suppressed LPS-elicited mRNA expression of pro-inflammatory inducible nitric oxide synthase and tumor necrosis factor-alpha, and upregulated antioxidative enzyme axis Nrf2 and heme oxygenase-1, possibly via ERK but not AKT signaling pathways. Therefore, carboxyl-GdN@C held a great promise in becoming a novel theranostic nanoplatform for simultaneously deliver MRI contrast and therapeutic functions to inflammation-related diseases.
摘要
研究了新型磁共振成像（MRI）造影剂三金属氮化物笼状富勒烯羧基-GdN@C 的抗氧化和抗炎作用。所有的氢氯沙隆和羧基功能化富勒烯都表现出有效的自由基（羟基和超氧阴离子）清除作用，而羧基-GdN@C 则更有效地减轻了巨噬细胞中脂多糖（LPS）诱导的氧化应激。羧基-GdN@C 还抑制了 LPS 诱导的促炎诱导型一氧化氮合酶和肿瘤坏死因子-α的 mRNA 表达，并上调了抗氧化酶轴 Nrf2 和血红素加氧酶-1，可能通过 ERK 而不是 AKT 信号通路。因此，羧基-GdN@C 有望成为一种新型的治疗诊断纳米平台，可同时将 MRI 对比剂和治疗功能递送到与炎症相关的疾病。
相似文献
1
Trimetallic Nitride Endohedral Fullerenes Carboxyl-GdN@C: A New Theranostic Agent for Combating Oxidative Stress and Resolving Inflammation.三金属氮化物包合物富勒烯羧基-GdN@C：一种用于对抗氧化应激和解决炎症的新型治疗诊断一体化试剂。
ACS Appl Mater Interfaces. 2017 May 31;9(21):17681-17687. doi: 10.1021/acsami.7b04718. Epub 2017 May 19.
2
Amine Functionalized Trimetallic Nitride Endohedral Fullerenes: A Class of Nanoparticle to Tackle Low Back/Leg Pain.胺功能化三金属氮化物包合物富勒烯：一类用于治疗下背部/腿部疼痛的纳米颗粒
ACS Appl Bio Mater. 2022 Jun 20;5(6):2943-2955. doi: 10.1021/acsabm.2c00269. Epub 2022 May 16.
4
Gd3N@C84(OH)x: a new egg-shaped metallofullerene magnetic resonance imaging contrast agent.Gd3N@C84(OH)x：一种新型蛋形金属富勒烯磁共振成像造影剂。
J Am Chem Soc. 2014 Feb 12;136(6):2630-6. doi: 10.1021/ja412254k. Epub 2014 Feb 3.
5
A New Interleukin-13 Amino-Coated Gadolinium Metallofullerene Nanoparticle for Targeted MRI Detection of Glioblastoma Tumor Cells.一种新型白细胞介素-13 氨化钆金属富勒烯纳米颗粒，用于胶质母细胞瘤肿瘤细胞的靶向 MRI 检测。
J Am Chem Soc. 2015 Jun 24;137(24):7881-8. doi: 10.1021/jacs.5b03991. Epub 2015 Jun 11.
6
Use of trimetasphere metallofullerene MRI contrast agent for the non-invasive longitudinal tracking of stem cells in the lung.使用三棱镜金属富勒烯磁共振成像造影剂对肺部干细胞进行无创纵向追踪。
Methods. 2016 Apr 15;99:99-111. doi: 10.1016/j.ymeth.2015.11.004. Epub 2015 Nov 10.
7
Endohedral metal-induced regioselective formation of bis-Prato adduct of Y3N@I(h)-C80 and Gd3N@I(h)-C80.内包金属诱导的 Y3N@I(h)-C80 和 Gd3N@I(h)-C80 的双 Prato 加合物的区域选择性形成。
J Am Chem Soc. 2015 Jan 14;137(1):58-61. doi: 10.1021/ja511008z. Epub 2014 Dec 30.
8
Synthesis and purification of a metallic nitride fullerene bisadduct: exploring the reactivity of Gd3N@C80.金属氮化物富勒烯双加合物的合成与纯化：探索Gd3N@C80的反应活性
J Am Chem Soc. 2005 Sep 21;127(37):12776-7. doi: 10.1021/ja0535312.
10
Gd3N@C2n (n = 40, 42, and 44): remarkably low HOMO-LUMO gap and unusual electrochemical reversibility of Gd3N@C88 .Gd3N@C2n（n = 40、42和44）：Gd3N@C88具有极低的最高占据分子轨道-最低未占据分子轨道能隙和异常的电化学可逆性。
J Am Chem Soc. 2007 Nov 28;129(47):14826-9. doi: 10.1021/ja075930y. Epub 2007 Nov 6.
引用本文的文献
1
Water-soluble endohedral metallofullerenes: new horizons for biomedical applications.水溶性笼型金属富勒烯：生物医学应用的新领域。
Chem Commun (Camb). 2023 Nov 14;59(91):13551-13561. doi: 10.1039/d3cc03603k.
2
Amine Functionalized Trimetallic Nitride Endohedral Fullerenes: A Class of Nanoparticle to Tackle Low Back/Leg Pain.胺功能化三金属氮化物包合物富勒烯：一类用于治疗下背部/腿部疼痛的纳米颗粒
ACS Appl Bio Mater. 2022 Jun 20;5(6):2943-2955. doi: 10.1021/acsabm.2c00269. Epub 2022 May 16.
3
Single-cell assessment of the modulation of macrophage activation by ex vivo intervertebral discs using impedance cytometry.采用阻抗细胞术对离体椎间盘中巨噬细胞激活的调节进行单细胞评估。
Biosens Bioelectron. 2022 Aug 15;210:114346. doi: 10.1016/j.bios.2022.114346. Epub 2022 May 7.
4
Recent advances in nanomaterials for therapy and diagnosis for atherosclerosis.纳米材料在动脉粥样硬化治疗和诊断中的最新进展。
Adv Drug Deliv Rev. 2021 Mar;170:142-199. doi: 10.1016/j.addr.2021.01.005. Epub 2021 Jan 9.
5
Microfluidic Disc-on-a-Chip Device for Mouse Intervertebral Disc-Pitching a Next-Generation Research Platform To Study Disc Degeneration.用于小鼠椎间盘的微流控芯片上圆盘装置——打造研究椎间盘退变的下一代研究平台
ACS Biomater Sci Eng. 2019 Apr 8;5(4):2041-2051. doi: 10.1021/acsbiomaterials.8b01522. Epub 2019 Feb 26.
6
Studies Exploring the Interaction of the Organophosphorus Compound Paraoxon with Fullerenes.探索有机磷化合物对氧磷与富勒烯相互作用的研究。
ACS Omega. 2019 Oct 28;4(20):18663-18667. doi: 10.1021/acsomega.9b02587. eCollection 2019 Nov 12.
7
A New Formyl Peptide Receptor-1 Antagonist Conjugated Fullerene Nanoparticle for Targeted Treatment of Degenerative Disc Diseases.一种新型的甲酰肽受体-1 拮抗剂偶联富勒烯纳米颗粒，用于退行性椎间盘疾病的靶向治疗。
ACS Appl Mater Interfaces. 2019 Oct 23;11(42):38405-38416. doi: 10.1021/acsami.9b11783. Epub 2019 Oct 8.
本文引用的文献
1
Pannexin hemichannels: A novel promising therapy target for oxidative stress related diseases.泛连接蛋白半通道：氧化应激相关疾病一个新的有前景的治疗靶点。
J Cell Physiol. 2018 Mar;233(3):2075-2090. doi: 10.1002/jcp.25906. Epub 2017 May 3.
2
Mechanism of ROS scavenging and antioxidant signalling by redox metallic and fullerene nanomaterials: Potential implications in ROS associated degenerative disorders.氧化应激相关金属纳米材料和富勒烯纳米材料的 ROS 清除和抗氧化信号传导机制：在 ROS 相关退行性疾病中的潜在意义。
Biochim Biophys Acta Gen Subj. 2017 Apr;1861(4):802-813. doi: 10.1016/j.bbagen.2017.01.018. Epub 2017 Jan 20.
3
Detecting Chronic Post-Traumatic Osteomyelitis of Mouse Tibia via an IL-13Rα2 Targeted Metallofullerene Magnetic Resonance Imaging Probe.通过白细胞介素-13受体α2靶向金属富勒烯磁共振成像探针检测小鼠胫骨慢性创伤后骨髓炎
Bioconjug Chem. 2017 Feb 15;28(2):649-658. doi: 10.1021/acs.bioconjchem.6b00708. Epub 2017 Feb 6.
4
Biomedical Applications of Metal-Encapsulated Fullerene Nanoparticles.金属封装富勒烯纳米粒子在生物医学中的应用。
Small. 2017 Feb;13(8). doi: 10.1002/smll.201603152. Epub 2016 Dec 27.
5
Heme oxygenase (HO)-1 induction prevents Endoplasmic Reticulum stress-mediated endothelial cell death and impaired angiogenic capacity.血红素加氧酶-1（HO-1）诱导可防止内质网应激介导的内皮细胞死亡和受损的血管生成能力。
Biochem Pharmacol. 2017 Mar 1;127:46-59. doi: 10.1016/j.bcp.2016.12.009. Epub 2016 Dec 21.
6
Oxidative stress in cancer and fibrosis: Opportunity for therapeutic intervention with antioxidant compounds, enzymes, and nanoparticles.癌症与纤维化中的氧化应激：抗氧化化合物、酶及纳米颗粒的治疗干预机遇
Redox Biol. 2017 Apr;11:240-253. doi: 10.1016/j.redox.2016.12.011. Epub 2016 Dec 16.
7
Substance P Induces HO-1 Expression in RAW 264.7 Cells Promoting Switch towards M2-Like Macrophages.P物质诱导RAW 264.7细胞中血红素加氧酶-1表达，促进向M2样巨噬细胞转变。
PLoS One. 2016 Dec 1;11(12):e0167420. doi: 10.1371/journal.pone.0167420. eCollection 2016.
8
Gd@C metallofullerenes for neutron capture therapy-fullerene solubilization by poly(ethylene glycol)-block-poly(2-(, -diethylamino)ethyl methacrylate) and resultant efficacy .用于中子俘获治疗的钆内嵌富勒烯——聚（乙二醇）-嵌段-聚（2-（N，N-二乙氨基）甲基丙烯酸乙酯）对富勒烯的增溶作用及由此产生的疗效
Sci Technol Adv Mater. 2011 Jul 7;12(4):044607. doi: 10.1088/1468-6996/12/4/044607. eCollection 2011 Aug.
9
Gd@C-(ethylenediamine) Nanoparticle: A New High-Efficiency Water-Soluble ROS Scavenger.钆@C-(乙二胺)纳米颗粒：一种新型高效水溶性 ROS 清除剂。
ACS Appl Mater Interfaces. 2016 Oct 5;8(39):25770-25776. doi: 10.1021/acsami.6b08659. Epub 2016 Sep 22.
10
A New Interleukin-13 Amino-Coated Gadolinium Metallofullerene Nanoparticle for Targeted MRI Detection of Glioblastoma Tumor Cells.一种新型白细胞介素-13 氨化钆金属富勒烯纳米颗粒，用于胶质母细胞瘤肿瘤细胞的靶向 MRI 检测。
J Am Chem Soc. 2015 Jun 24;137(24):7881-8. doi: 10.1021/jacs.5b03991. Epub 2015 Jun 11.
Zotero 插件