Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA/Corinne Goldsmith Dickinson Center for Multiple Sclerosis, Mount Sinai Hospital, New York, NY, USA.
Department of Neurology, Columbia University Medical Center, New York, NY, USA.
Mult Scler. 2018 Apr;24(5):675-678. doi: 10.1177/1352458517708873. Epub 2017 May 18.
BACKGROUND/OBJECTIVE: Memory deficits due to multiple sclerosis (MS) have been variably linked to lower subcortical grey matter (SCGM) and mesial temporal lobe (MTL) volumes. We investigated which is the better predictor and whether this changes across disease stages.
METHODS/RESULTS: Memory was assessed in 315 patients. Magnetic resonance imaging (MRI) measured volumes of total brain, grey matter, white matter, MTL (hippocampus, amygdala) and SCGM (thalamus, caudate). MTL predicted memory in the total sample and in patients with earlier (<10 years) or later (⩾10 years) relapsing disease. SCGM (specifically thalamus) predicted memory in progressive patients.
Neuroanatomical correlates of memory deficits differ across disease stages.
背景/目的：多发性硬化症（MS）导致的记忆缺陷与较低的皮质下灰质（SCGM）和内侧颞叶（MTL）体积有关。我们研究了哪一个是更好的预测指标，以及在疾病阶段是否会发生变化。
方法/结果：对 315 名患者进行了记忆评估。磁共振成像（MRI）测量了大脑总容量、灰质、白质、MTL（海马体、杏仁核）和 SCGM（丘脑、尾状核）的体积。在总样本和早期（<10 年）或晚期（⩾10 年）复发疾病的患者中，MTL 可预测记忆。在进展性患者中，SCGM（特别是丘脑）可预测记忆。
记忆缺陷的神经解剖学相关因素在疾病阶段不同。
