Kumar Sonu, Mujahid Mohammad, Verma Akhilesh K
Synthetic Organic Chemistry Research Laboratory, Department of Chemistry, University of Delhi, Delhi 110007, India.
Org Biomol Chem. 2017 May 31;15(21):4686-4696. doi: 10.1039/c7ob00671c.
A facile approach for the synthesis of substituted iodo-benzo[a]phenazines from 2-aryl-3-(aryl/alkylethynyl)quinoxalines via 6-endo-dig ring closure has been described under mild reaction conditions. Iodocyclization proceeds through the iodonium ion intermediate followed by nucleophilic cyclization with the C-H bond of the arene. Furthermore, the resulting 6-iodo-5-aryl/alkyl benzo[a]phenazine derivatives allowed for structural diversification by employing various coupling reactions. The structure of iodo-benzo[a]phenazine was confirmed by X-ray crystallographic studies of the compound.
已经描述了一种在温和反应条件下，通过6-内型-亲核环化反应从2-芳基-3-(芳基/烷基乙炔基)喹喔啉合成取代碘代苯并[a]吩嗪的简便方法。碘环化反应通过碘鎓离子中间体进行，随后与芳烃的C-H键发生亲核环化反应。此外，通过各种偶联反应，所得的6-碘-5-芳基/烷基苯并[a]吩嗪衍生物实现了结构多样化。碘代苯并[a]吩嗪的结构通过该化合物的X射线晶体学研究得以证实。
