Song X, Sahoo N, Wu R, Taylor M, Georges R, Zhu X, Summers P, Gillin M
MD Anderson Cancer Center, Houston, TX.
Med Phys. 2012 Jun;39(6Part14):3770. doi: 10.1118/1.4735359.
To investigate the effect of source to surface distance on treatment field lateral penumbra width and the consequence of setup error on the dose distribution in the junction between two spinal fields of double scattered proton beams.
The CT images of the Spine Phantom from Radiological Physics Center was used to design a double scattered proton beam treatment plan using Varian Eclipse treatment planning system. PTV included spinal cord, vertebral body and part of spinous process. The PTV was divided into superior and inferior parts and two posterior fields were used to cover the targets with the prescribed dose. 2D dose was measured using IBA MatriXX and EBT2 film at a depth close to the center of SOBPs of both the fields located both at the nominal source to axis distance (SAD) of 270 cm and at an extended SAD. The field separation was changed by ±1 mm to study the effect of setup error. The measured and TPS calculated dose distributions in verification plans in a water phantom were compared.
The measured 2-D doses agreed very well with planned ones for individual fields. 99% of pixels pass 3%/3 mm dose/distance agreement criteria. The CAX dose differences are within 2%. The 80% to 20% penumbra widths at nominal SAD are 7.4/7.7/7.8 mm for planned/MatriXX/EBT2 film respectively, and about 1 mm wider for the extended SAD. The measured maximum dose was about 10% higher than that from the plan, and decreased/increased about 7% when the fields were separated by ±1 mm.
The penumbra width is modestly affected by the extended SSD often used for patient treatment. Dose in the junction of two fields is very sensitive to the setup error and the accuracy of the TPS dose calculation in this region may be limited.
研究源皮距对治疗野侧向半值层宽度的影响,以及摆位误差对双散射质子束两个脊髓野交界处剂量分布的影响。
使用放射物理中心的脊柱体模的CT图像,通过瓦里安Eclipse治疗计划系统设计双散射质子束治疗计划。计划靶区(PTV)包括脊髓、椎体和部分棘突。PTV分为上下两部分,使用两个后野以规定剂量覆盖靶区。在标称源轴距(SAD)为270 cm和延长源轴距的情况下,使用IBA MatriXX和EBT2胶片在接近两个野的剂量建成区中心深度处测量二维剂量。将野间距改变±1 mm,以研究摆位误差的影响。比较水模中验证计划中测量的和治疗计划系统(TPS)计算的剂量分布。
单个野的测量二维剂量与计划剂量非常吻合。99%的像素通过3%/3 mm剂量/距离一致性标准。中心轴剂量差异在2%以内。标称SAD下计划/MatriXX/EBT2胶片的80%至20%半值层宽度分别为7.4/7.7/7.8 mm,延长源轴距时宽约1 mm。测量的最大剂量比计划值高约10%,当野间距±1 mm分开时,剂量降低/增加约7%。
常用于患者治疗的延长源皮距对半值层宽度有一定影响。两个野交界处的剂量对摆位误差非常敏感,该区域TPS剂量计算的准确性可能有限。