Schwartz A, Grupp G, Wallick E, Grupp I L, Ball W J
Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, OH 45267-0575.
Prog Clin Biol Res. 1988;268B:321-38.
In terms of evolution, the Na+,K+-ATPase is one of the oldest proteins. It is intriguing that this membrane-based enzyme has become biologically consistent with a multifunctional protein. One of the most interesting aspects of the Na+,K+-ATPase is that it contains a specific receptor domain for the oldest plant origin cardiotonic drug and that it is involved in the regulation of myocardial contractility.
从进化的角度来看，钠钾ATP酶是最古老的蛋白质之一。有趣的是，这种基于膜的酶在生物学上已与一种多功能蛋白质相一致。钠钾ATP酶最有趣的方面之一是，它含有一种针对最古老的植物源性强心药物的特定受体结构域，并且参与心肌收缩力的调节。
