Brandão M L, Tomaz C, Borges P C, Coimbra N C, Bagri A
Laboratório de Psicobiologia, FFCLRP, Universidade de São Paulo, Brasil.
Physiol Behav. 1988;44(3):361-5. doi: 10.1016/0031-9384(88)90038-8.
Behavioral and autonomic effects of microinjections of bicuculline--a GABA receptor antagonist--into ventral aspects of the inferior colliculus (IC) produced a behavioral activation together with jumps. This activation was similar to escape behavior that has been induced from periventricular structures although it was neither as explosive as that observed from the dorsal periaqueductal gray matter (DPAG) nor as coordinated as that obtained from the medial hypothalamus (MH). In anesthetized rats, microinjection of bicuculline into the IC produced a clear rise in mean arterial blood pressure and in heart rate. These effects reached a maximum after 10 min and subsided within 20 min after injection. GABA receptor blockade in the IC of detelencephalated rats also resulted in escape behavior qualitatively similar to that observed in intact animals. These results suggest that in addition to the central gray and medial hypothalamus, GABA also exerts a tonic inhibitory action on neurons of the IC implicated in the generation or elaboration of aversive responses.
向下丘腹侧微量注射GABA受体拮抗剂荷包牡丹碱所产生的行为和自主神经效应，会引起行为激活并伴有跳跃。这种激活类似于从脑室周围结构诱发的逃避行为，尽管它既不像从导水管周围灰质背侧观察到的那样剧烈，也不像从中下丘脑获得的那样协调。在麻醉大鼠中，向下丘微量注射荷包牡丹碱会使平均动脉血压和心率明显升高。这些效应在注射后10分钟达到最大值，并在20分钟内消退。去大脑大鼠下丘中的GABA受体阻断也会导致与完整动物中观察到的定性相似的逃避行为。这些结果表明，除了中央灰质和下丘脑内侧外，GABA还对参与厌恶反应产生或细化的下丘神经元发挥紧张性抑制作用。
