Tomaz C, Brandão M, Bagri A, Carrive P, Schmitt P
Laboratory of Psychobiology, F.F.C.L.R.P., University of São Paulo, Ribeirão Preto, Brasil.
Pharmacol Biochem Behav. 1988 Jun;30(2):337-42. doi: 10.1016/0091-3057(88)90464-9.
Behavioral effects of unilateral microinjections into periventricular structures of bicuculline, a classic GABA-A antagonist, and semicarbazide, a glutamic acid decarboxylase blocker, were studied in detelencephalated rats. These drugs produced a behavioral activation together with jumps. However, the characteristics of this behavioral activation differed as the injections were made in dorsal periaqueductal gray matter or medial hypothalamus. These data show close similarities to those observed with intact animals suggesting that GABA-A receptors are involved in the neural control of expression of flight behavior and functions in an intact manner and possibly independent of influences from forebrain structures. At variance with intact animals, these drugs produced contralateral turning behavior when locally injected into MH, pointing to some kind of inhibitory control exerted by telencephalic structures on the expression of circling behavior from diencephalic regions.
在去大脑的大鼠中，研究了向脑室周围结构单侧微量注射经典GABA - A拮抗剂荷包牡丹碱和谷氨酸脱羧酶阻滞剂氨基脲的行为效应。这些药物产生了行为激活并伴有跳跃。然而，当注射到导水管周围灰质背侧或内侧下丘脑时，这种行为激活的特征有所不同。这些数据与在完整动物中观察到的数据非常相似，表明GABA - A受体参与了逃避行为表达的神经控制，并且以完整的方式发挥作用，可能独立于前脑结构的影响。与完整动物不同的是，这些药物局部注射到内侧下丘脑时会产生对侧转向行为，这表明端脑结构对间脑区域的转圈行为表达施加了某种抑制性控制。
