Lovelock D, Lim S, Yorke E, Kirov A, LoSasso T
Memorial Sloan-Kettering Cancer Center, New York, NY.
Med Phys. 2012 Jun;39(6Part18):3828. doi: 10.1118/1.4735621.
Accurate modeling of the dose distribution in a lung tumor is challenging for traditional dose calculation algorithms. We compare the dose distributions of four commercial dose calculation Methods: Raysearch (Raysearch Laboratories) and Pinnacle (Philips Healthcare) collapsed cone, and Eclipse AAA and Eclipse Acuros,(Varian Medical Systems) with measurements using radiochromic film in a lung tumor phantomMethods: A simple lung tumor phantom was constructed using a thermoplastic cylinder 29 mm diameter and 40mm in length (density 1.3 gm/cc) imbedded in cork phantom 25 × 25 × 20 cm of density 0.32 gm/cc. Nine film layers normal to the axis of the cylinder where placed between layers of cork, above, below and through the cylindrical inhomogeneity. The phantom was irradiated with a single asymmetric 10×10 cm 6 MV field with the central axis collinear with the cylinder axis. Thirteen film exposures at 5 cm depth taken with doses 0-10 Gy were used to calibrate the film. The phantom was CT scanned and the DICOM study loaded into each of the treatment planning systems to calculate the dose distribution in the phantom.
Away from cork-poly interfaces, agreement between the four algorithms was within 3% of the film measurements. For Acuros, the dose at the edge of the cylinder was found to be up to 2% lower than that at the center of the cylinder possibly because of the loss of lateral electron equilibrium.
All four algorithms achieved remarkable agreement with the radiochromic film measurement. The Acuros algorithm appeared to more accurately model the peripheral dose deficit in the tumor, although a more detailed study is required for confirmation.
对于传统剂量计算算法而言,准确模拟肺肿瘤中的剂量分布具有挑战性。我们比较了四种商业剂量计算方法的剂量分布:Raysearch(Raysearch Laboratories公司)和Pinnacle(飞利浦医疗保健公司)的坍缩圆锥算法,以及Eclipse AAA和Eclipse Acuros(瓦里安医疗系统公司)算法,并在肺肿瘤体模中使用放射变色胶片进行测量。
使用一个直径29毫米、长度40毫米(密度1.3克/立方厘米)的热塑性圆柱体嵌入一个密度为0.32克/立方厘米、尺寸为25×25×20厘米的软木体模中,构建一个简单的肺肿瘤体模。在圆柱体轴向上垂直放置九层胶片,置于软木层之间,分别位于圆柱体不均匀性的上方、下方及穿过该不均匀性区域。使用一个不对称的10×10厘米6兆伏射野对体模进行照射,中心轴与圆柱体轴共线。利用在5厘米深度处、剂量为0 - 10戈瑞的13次胶片曝光来校准胶片。对体模进行CT扫描,并将DICOM研究数据加载到每个治疗计划系统中,以计算体模中的剂量分布。
在远离软木 - 塑料界面处,四种算法与胶片测量结果的一致性在3%以内。对于Acuros算法,发现圆柱体边缘的剂量比圆柱体中心的剂量低达2%,这可能是由于横向电子平衡的丧失。
所有四种算法与放射变色胶片测量结果都达成了显著的一致性。Acuros算法似乎能更准确地模拟肿瘤周边的剂量不足,不过仍需要更详细的研究来证实。