Tucker A, Gidcumb E, Shan J, Qian X, Sprenger F, Spronk D, Zhang Y, Kennedy D, Farbizio T, Ruth C, Jing Z, Lu J, Zhou O
University of North Carolina at Chapel Hill, Chapel Hill, NC.
Xinray Systems LLC, RTP, NC.
Med Phys. 2012 Jun;39(6Part24):3916. doi: 10.1118/1.4735983.
In conventional Digital Breast Tomosynthesis (DBT) systems a single x-ray source moves over a limited angle arc. This leads to motion blurring in the projection images associated with x-ray source motion and total scan times. We have developed a stationary DBT (s-DBT) system which forgoes a rotating source for an array of carbon nanotube (CNT) based x-ray sources. Here we report the results of evaluating the performance and the optimization of image acquisition parameters of the s-DBT system.
The s-DBT system consists of a linear source array with 31 x-ray generating focal spots distributed over a 30 degree angular span. The source array has been retrofitted onto a Hologic Selenia Dimensions DBT system. An American College of Radiology accreditation phantom was imaged to assess the quality of the reconstruction images in different configurations. A line wire phantom is used to measure the modulation transfer function (MTF).
For the standard imaging protocol, the system resolution along the scanning direction is increased from 3.0 cycles/mm in DBT to 4.2 cycles/mm in s-DBT at a magnification factor of 1.08. The MTF did not have a noticeable change between different configurations, whereas in DBT the MTF can be degraded for larger angular spans due to faster x-ray source motion. The overall image quality factor is found to be best for the configuration with a large angular span and intermittent number of projection views.
We demonstrated successful construction and operation of the s-DBT system integrating a CNT x-ray source array with a Hologic DBT system. The spatial resolution of the s-DBT system is demonstrated to be substantially increased over the corresponding DBT system. It was found that a configuration with a large angular span, an intermittent number of projection views, and an even dose distribution resulted in the best overall image quality. Hologic INC has provided the Hologic Selenia Dimensions used in the research. The project is supported by the National Cancer Institute under grant number U54CA119343 and R01CA134598 and the UNC University Cancer Research Fund. Dr. Xin Qian is supported by a fellowship from the Department of Defense under grant number BC087505.
在传统数字乳腺断层合成(DBT)系统中,单个X射线源在有限角度的弧上移动。这会导致与X射线源运动和总扫描时间相关的投影图像出现运动模糊。我们开发了一种固定式DBT(s-DBT)系统,该系统放弃了旋转源,采用基于碳纳米管(CNT)的X射线源阵列。在此,我们报告评估s-DBT系统性能及优化图像采集参数的结果。
s-DBT系统由一个线性源阵列组成,该阵列有31个X射线产生焦点,分布在30度的角跨度上。该源阵列已改装到Hologic Selenia Dimensions DBT系统上。对一个美国放射学会认证体模进行成像,以评估不同配置下重建图像的质量。使用线丝体模测量调制传递函数(MTF)。
对于标准成像协议,在放大倍数为1.08时,系统沿扫描方向的分辨率从DBT中的3.0周期/毫米提高到s-DBT中的4.2周期/毫米。不同配置之间MTF没有明显变化,而在DBT中,由于X射线源运动更快,较大角跨度下MTF可能会下降。发现对于具有大角跨度和间歇投影视图数量的配置,整体图像质量因子最佳。
我们展示了将CNT X射线源阵列与Hologic DBT系统集成的s-DBT系统的成功构建和运行。结果表明,s-DBT系统的空间分辨率比相应的DBT系统有显著提高。发现具有大角跨度、间歇投影视图数量和均匀剂量分布的配置产生了最佳的整体图像质量。Hologic INC提供了研究中使用的Hologic Selenia Dimensions。该项目由美国国立癌症研究所资助,资助编号为U54CA119343和R01CA134598,以及北卡罗来纳大学癌症研究基金。钱欣博士由美国国防部资助,资助编号为BC087505。