Haggstrom Lucy, Welschinger Robert, Caplan Gideon A
University of New South Wales, Sydney, New South Wales, Australia.
Department of Geriatric Medicine, Prince of Wales Hospital, Sydney, New South Wales, Australia.
Australas J Ageing. 2017 Sep;36(3):186-192. doi: 10.1111/ajag.12417. Epub 2017 May 18.
This systematic review describes the current functional neuroimaging literature in delirium, discusses pathophysiological implications of these results and highlights areas for further study.
In accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, an extensive search of medical databases was undertaken, identifying eighteen studies of variable quality and design suitable for inclusion.
Functional neuroimaging has highlighted significant abnormalities during delirium, with disturbances in cerebral haemodynamics and functional connectivity potentially playing a key role in delirium pathophysiology.
Although employing functional neuroimaging in delirium remains difficult, these findings demonstrate the potential of functional imaging to increase our understanding of the underlying mechanisms of delirium, to lead to more efficient interventions and targeted therapies and to reduce the burden of this underdiagnosed syndrome.
本系统评价描述了当前关于谵妄的功能神经影像学文献，讨论了这些结果的病理生理学意义，并突出了进一步研究的领域。
按照系统评价和Meta分析的首选报告项目指南，对医学数据库进行了广泛检索，确定了18项质量和设计各异但适合纳入的研究。
功能神经影像学突出显示了谵妄期间的显著异常，脑血流动力学和功能连接的紊乱可能在谵妄病理生理学中起关键作用。
尽管在谵妄中应用功能神经影像学仍然困难，但这些发现证明了功能成像在增强我们对谵妄潜在机制的理解、促成更有效的干预措施和靶向治疗以及减轻这种诊断不足综合征的负担方面的潜力。
