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1H-吡唑并[4,3-d]嘧啶-7(6H)-酮和吡唑并-5-甲酰胺的合成及其与大鼠大脑皮质中苯二氮䓬受体和腺苷A1受体的相互作用

Synthesis of 1H-pyrazolo[4,3-d]pyrimidine-7(6H)-ones and pyrazolo-5-carboxamides and interaction with benzodiazepine and adenosine A1 receptors in rat cerebral cortex.

作者信息

Baraldi P G, Casolari A, Manfredini S, Periotto V, Zanirato V, Florio C, Traversa V, Bertelli G M, Borea P A

机构信息

Dipartimento di Scienze Farmaceutiche, Università di Ferrara, Italy.

出版信息

Arzneimittelforschung. 1988 Sep;38(9):1262-5.

PMID:2852012
Abstract

The effects of several newly synthesized pyrazolo [4,3-d] pyrimidine-7-ones and pyrazolo-5-carboxamides on [3H]-flunitrazepam and [3H]-cyclohexyladenosine binding in rat cerebral cortex membranes have been studied. The compounds under examination, displaying affinities in the micromolar range for both benzodiazepine and adenosine A1 receptors, could be of interest in the study of a possible link between the two receptor systems.

摘要

研究了几种新合成的吡唑并[4,3 - d]嘧啶 - 7 - 酮和吡唑并 - 5 - 甲酰胺对大鼠大脑皮层膜中[3H] - 氟硝西泮和[3H] - 环己基腺苷结合的影响。所检测的化合物对苯二氮䓬和腺苷A1受体均显示出微摩尔范围内的亲和力，可能在研究这两种受体系统之间的潜在联系方面具有意义。

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