三环杂芳族体系吡唑并[1,5 - a]喹喔啉：合成及苯二氮䓬受体活性

Tricyclic heteroaromatic systems pyrazolo[1,5-a]quinoxalines: synthesis and benzodiazepine receptor activity.

作者信息

Colotta V, Cecchi L, Catarzi D, Conti G, Filacchioni G, Martini C, Giusti L, Lucacchini A

机构信息

Dipartimento di Scienze Farmaceutiche, Università di Firenze, Italy.

出版信息

Farmaco. 1993 Aug;48(8):1051-63.

Abstract

The synthesis and the benzodiazepine receptor activity of some pyrazolo[1,5-a]quinoxalines bearing various substituents on the tricyclic heteroaromatic system are reported. Only one of the tested compounds showed some receptor affinity.

摘要

报道了一些在三环杂芳环系统上带有各种取代基的吡唑并[1,5-a]喹喔啉的合成及其苯二氮䓬受体活性。所测试的化合物中只有一种显示出一定的受体亲和力。

相似文献

1

Tricyclic heteroaromatic systems pyrazolo[1,5-a]quinoxalines: synthesis and benzodiazepine receptor activity.三环杂芳族体系吡唑并[1,5 - a]喹喔啉：合成及苯二氮䓬受体活性

Farmaco. 1993 Aug;48(8):1051-63.

2

Tricyclic heteroaromatic systems 1,2,4-triazolo[1,5-a]quinoxalines: synthesis and benzodiazepine receptor activity.三环杂芳族体系1,2,4-三唑并[1,5-a]喹喔啉：合成及苯二氮䓬受体活性

Farmaco. 1993 Aug;48(8):1065-78.

3

Synthesis of 7-(2-dimethylaminovinyl) derivatives of pyrazolo[1,5-a] pyrimidines, as precursors of new tricyclic series. Binding studies of BDZ receptor.吡唑并[1,5 - a]嘧啶的7 -（2 - 二甲基氨基乙烯基）衍生物的合成，作为新的三环系列的前体。苯二氮䓬受体的结合研究。

Farmaco. 1993 Feb;48(2):309-19.

4

Reaction of 1-aminophthalazines with alpha-halocarbonyl compounds: imidazo[2,1-a]phthalazines and their benzodiazepine receptor activities.1-氨基酞嗪与α-卤代羰基化合物的反应：咪唑并[2,1-a]酞嗪及其苯二氮䓬受体活性

Farmaco. 1993 Apr;48(4):447-57.

5

Dipyrazolo[5,4-b:3',4'-d]pyridines. Synthesis, inhibition of benzodiazepine receptor binding and structure-activity relationships.二吡唑并[5,4 - b:3',4' - d]吡啶。合成、苯二氮䓬受体结合抑制及构效关系

Farmaco. 1989 Jun;44(6):585-94.

6

Synthesis and binding study on pyrazolo[4,5-c] [1,8]naphthyridines.吡唑并[4,5-c][1,8]萘啶的合成与结合研究

Farmaco Sci. 1987 Sep;42(9):671-80.

7

Pyrazolo [4,3-c] quinolines synthesis and specific inhibition of benzodiazepine receptor binding (Note I).吡唑并[4,3 - c]喹啉的合成及对苯二氮䓬受体结合的特异性抑制（注释I）

Farmaco. 1993 Jan;48(1):65-76.

8

New 2,3-substituted 4,7-dihydro-6-(1'H-pyrazol-3'-yl)pyrazolo[1,5-a] pyrimidin-7-ones and related compounds: synthesis and benzodiazepine receptor binding study.新型2,3-取代的4,7-二氢-6-(1'H-吡唑-3'-基)吡唑并[1,5-a]嘧啶-7-酮及相关化合物：合成与苯二氮䓬受体结合研究

Farmaco. 1995 Oct;50(10):679-87.

9

Synthesis of 1H-pyrazolo[4,3-d]pyrimidine-7(6H)-ones and pyrazolo-5-carboxamides and interaction with benzodiazepine and adenosine A1 receptors in rat cerebral cortex.1H-吡唑并[4,3-d]嘧啶-7(6H)-酮和吡唑并-5-甲酰胺的合成及其与大鼠大脑皮质中苯二氮䓬受体和腺苷A1受体的相互作用

Arzneimittelforschung. 1988 Sep;38(9):1262-5.

10

Synthesis and binding activity of some pyrazolo[1,5-c]quinazolines as tools to verify an optional binding site of a benzodiazepine receptor ligand.某些吡唑并[1,5-c]喹唑啉类化合物作为验证苯二氮䓬受体配体一个可选结合位点工具的合成与结合活性

J Med Chem. 1996 Jul 19;39(15):2915-21. doi: 10.1021/jm9509206.

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验