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[利用自旋标记法研究链霉素中毒猫的脑膜结构]

[Use of the spin label method for studying the structure of the brain membranes in cats with streptomycin poisoning].

作者信息

Maksina A G, Daĭniak B A, Rakhmanova I V

出版信息

Nauchnye Doki Vyss Shkoly Biol Nauki. 1988(11):61-4.

PMID:2852035
Abstract

The structural changes in cat brain membranes under the injections of intramuscular streptomycin which is ototoxic antibiotic have been studied. The increase of membrane microviscosity in brain areas which are the direct projection of the auditory way has been revealed using fat acidic spin probe on the basis of stearic acid. The changes in membranes of other brain areas have not been found that exhibits a specific streptomycin influence on the auditory analyzer. The EPR spectra of the hydrocarbon spin label C12H25 localizing in near membrane region don't change in brain membranes of experimental animals compared with the normal ones.

摘要

对注射具有耳毒性的抗生素——肌肉注射链霉素后猫脑膜的结构变化进行了研究。基于硬脂酸,使用脂肪酸自旋探针揭示了听觉通路直接投射的脑区中膜微粘度的增加。未发现其他脑区的膜有变化,这表明链霉素对听觉分析仪有特异性影响。与正常动物相比,定位在膜附近区域的烃类自旋标记物C12H25在实验动物脑膜中的电子顺磁共振光谱没有变化。

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