Chen Weiqiang, Yang Jinhua, Li Bingbing, Peng Guoyi, Li Tianfei, Li Lianjie, Wang Shousen
Department of Neurosurgery, Fuzhou General Hospital, Xiamen University Medical College, Fuzhou, China (Drs Chen, B. Li, T. Li, L. Li, and Wang); and Department of Neurosurgery, First Affiliated Hospital, Shantou University Medical College, Shantou, Guangdong, China (Drs Yang and Peng).
J Head Trauma Rehabil. 2018 Jan/Feb;33(1):E53-E59. doi: 10.1097/HTR.0000000000000320.
The neutrophil to lymphocyte ratio (NLR) has been reported to be a predictor of outcome in critical illness. Objective of this study was to investigate the changes of the NLR in patients with severe traumatic brain injury (TBI) and analyze the relationship between the NLR and TBI outcome.
China.
A total of 855 patients with severe TBI from January 2007 to April 2012.
Retrospective.
Data on the NLR and other indicators were collected. After follow-up until death or 1 year, the relationship between the NLR and TBI outcome was analyzed retrospectively.
The final analysis included 688 patients. There were 508 (73.8%) who had an unfavorable outcome by 1 year after head trauma. The value of the NLR on admission was significantly higher in the unfavorable outcome group than in the favorable outcome group (P < .001). Multivariate logistic analysis showed that higher NLR was associated with an unfavorable outcome (odds ratio, 1.100; P < .001). Receiver operating characteristic curve analysis showed that the NLR had a sensitivity of 60.2% and a specificity of 71.1% for predicting unfavorable outcome at 1 year on the basis of the best threshold.
The NLR might be useful as a novel predictor for 1-year outcome and mortality in severe TBI.
据报道，中性粒细胞与淋巴细胞比值（NLR）是危重病预后的一个预测指标。本研究的目的是调查重型颅脑损伤（TBI）患者NLR的变化，并分析NLR与TBI预后之间的关系。
中国。
2007年1月至2012年4月期间共855例重型TBI患者。
回顾性研究。
收集NLR及其他指标的数据。随访至死亡或1年，回顾性分析NLR与TBI预后之间的关系。
最终分析纳入688例患者。其中508例（73.8%）在颅脑外伤后1年预后不良。预后不良组入院时的NLR值显著高于预后良好组（P <.001）。多因素logistic分析显示，较高的NLR与不良预后相关（比值比，1.100；P <.001）。受试者工作特征曲线分析显示，基于最佳阈值，NLR预测1年不良预后的敏感性为60.2%，特异性为71.1%。
NLR可能作为重型TBI患者1年预后和死亡率的一种新的预测指标。
