Department of Neurosurgery, Changzheng Hospital, Second Military Medical University, Shanghai, China.
Neurocrit Care. 2019 Apr;30(2):334-339. doi: 10.1007/s12028-018-0622-9.
Studies suggested that the neutrophil-to-lymphocyte ratio (NLR) was associated with unfavorable outcomes in different diseases such as intracerebral hemorrhage, cardiovascular problem, cancer, and severe traumatic brain injury (sTBI). We aimed to evaluate the relationship between peak NLR and 1-year outcomes in patients with sTBI.
We retrospectively reviewed the clinical data of patients with sTBI who were treated in our department between January 2013 and January 2017. NLRs between day 1 and day 12 after admission as well as other related indicators were collected. The relationship between peak NLR and 1-year outcomes was analyzed. Factors associated with larger peak NLR were also explored.
A total of 316 patients were included, and 81.3% (257/316) experienced unfavorable outcomes. Peak NLR was identified as an independent predictor for unfavorable outcomes after sTBI in multivariable logistic regression analysis (odds ratio, 1.086; 95% confidence interval, 1.037-1.137; P < 0.001). Its predictive value was confirmed by receiver operating characteristic analysis (area under curve = 0.775; P < 0.001). The day 1 NLR as well as admission Glasgow Coma Scale score was independently correlated with increased peak NLR.
Peak NLR was associated with the clinical prognosis after sTBI and was a promising predictor for 1-year outcomes.
研究表明，中性粒细胞与淋巴细胞比值（NLR）与不同疾病的不良结局相关，如脑出血、心血管问题、癌症和严重创伤性脑损伤（sTBI）。我们旨在评估 sTBI 患者入院后第 1 天至第 12 天 NLR 峰值与 1 年结局之间的关系。
我们回顾性分析了 2013 年 1 月至 2017 年 1 月在我科治疗的 sTBI 患者的临床资料。收集入院后第 1 天至第 12 天的 NLR 及其他相关指标。分析峰值 NLR 与 1 年结局的关系。还探讨了与更大峰值 NLR 相关的因素。
共纳入 316 例患者，81.3%（257/316）发生不良结局。多变量逻辑回归分析显示，峰值 NLR 是 sTBI 后不良结局的独立预测因子（优势比，1.086；95%置信区间，1.037-1.137；P<0.001）。受试者工作特征曲线分析验证了其预测价值（曲线下面积=0.775；P<0.001）。入院第 1 天的 NLR 和格拉斯哥昏迷量表评分与峰值 NLR 的升高独立相关。
峰值 NLR 与 sTBI 后的临床预后相关，是 1 年结局的有前途的预测因子。
