Barrett G L, Morgan T O, Smith M
Department of Physiology, University of Melbourne, Parkville, Australia.
Clin Exp Hypertens A. 1988;10(6):1279-82. doi: 10.1080/07300077.1988.11878918.
This study examined the effect of exogenous AI and AII on renin synthesis and release. AII or AII + AI were given using osmotic minipumps, over a 7 day period to rats receiving oral Enalapril. Enalapril caused a marked increase in renin release and synthesis. AII abolished the rise in plasma and renal renin observed with Enalapril. AI had no inhibitory or stimulatory effect on renin release or synthesis in rats receiving Enalapril and AII.
本研究检测了外源性血管紧张素Ⅰ（AI）和血管紧张素Ⅱ（AII）对肾素合成与释放的影响。通过渗透微型泵给接受口服依那普利的大鼠持续7天给予AII或AII + AI。依那普利使肾素释放和合成显著增加。AII消除了依那普利所致的血浆和肾脏肾素升高。AI对接受依那普利和AII的大鼠的肾素释放或合成没有抑制或刺激作用。
