Kim Hyoung F, Amita Hidetoshi, Hikosaka Okihide
Department of Biomedical Engineering, Sungkyunkwan University (SKKU), Suwon 16419, Republic of Korea; Center for Neuroscience Imaging Research, Institute for Basic Science (IBS), Suwon 16419, Republic of Korea.
Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Neuron. 2017 May 17;94(4):920-930.e3. doi: 10.1016/j.neuron.2017.04.033.
The striatum controls behavior in two ways: facilitation and suppression through the direct and indirect pathways, respectively. However, it is still unclear what information is processed in these pathways. To address this question, we studied two pathways originating from the primate caudate tail (CDt). We found that the CDt innervated the caudal-dorsal-lateral part of the substantia nigra pars reticulata (cdlSNr), directly or indirectly through the caudal-ventral part of the globus pallidus externus (cvGPe). Notably, cvGPe neurons receiving inputs from the CDt were mostly visual neurons that encoded stable reward values of visual objects based on long-past experiences. Their dominant response was inhibition by valueless objects, which generated disinhibition of cdlSNr neurons and inhibition of superior colliculus neurons. Our data suggest that low-value signals are sent by the CDt-indirect pathway to suppress saccades to valueless objects, whereas high-value signals are sent by the CDt-direct pathway to facilitate saccades to valuable objects.
分别通过直接通路和间接通路进行促进和抑制。然而，这些通路中处理的是什么信息仍不清楚。为了解决这个问题，我们研究了源自灵长类动物尾状核尾部（CDt）的两条通路。我们发现，CDt直接或通过外侧苍白球腹侧部（cvGPe）间接支配黑质网状部的尾背外侧部（cdlSNr）。值得注意的是，接受CDt输入的cvGPe神经元大多是视觉神经元，它们基于长期过去的经验编码视觉对象的稳定奖励值。它们的主要反应是被无价值对象抑制，这会导致cdlSNr神经元去抑制和上丘神经元抑制。我们的数据表明，低价值信号通过CDt间接通路发送，以抑制对无价值对象的扫视，而高价值信号通过CDt直接通路发送，以促进对有价值对象的扫视。
