Laboratory of Sensorimotor Research, National Eye Institute, Bethesda, MD 20892, USA.
Sci Adv. 2019 Aug 7;5(8):eaaw9297. doi: 10.1126/sciadv.aaw9297. eCollection 2019 Aug.
The essential everyday task of making appropriate choices is a process controlled mainly by the basal ganglia. To this end, subjects need not only to find "good" objects in their environment but also to reject "bad" objects. To reveal this rejection mechanism, we created a sequential saccade choice task for monkeys and studied the role of the indirect pathway from the CDt (tail of the caudate nucleus) mediated by cvGPe (caudal-ventral globus pallidus externus). Neurons in cvGPe were typically inhibited by the appearance of bad objects; however, this inhibition was reduced on trials when the monkeys made undesired saccades to the bad objects. Moreover, disrupting the inhibitory influence of CDt on cvGPe by local injection of bicuculline (GABA receptor antagonist) impaired the monkeys' ability to suppress saccades to bad objects. Thus, the indirect pathway mediates the rejection of bad choices, a crucial component of goal-directed behavior.
做出适当选择的基本日常任务主要由基底神经节控制。为此，受试者不仅需要在环境中找到“好”的物体，还需要拒绝“坏”的物体。为了揭示这种拒绝机制，我们为猴子创建了一个连续扫视选择任务，并研究了由 cvGPe（尾状苍白球腹外侧部）介导的来自 CDt（尾状核）的间接通路的作用。cvGPe 中的神经元通常会因“坏”物体的出现而受到抑制；然而，当猴子不希望向“坏”物体进行扫视时，这种抑制会减少。此外，通过局部注射荷包牡丹碱（GABA 受体拮抗剂）破坏 CDt 对 cvGPe 的抑制性影响会损害猴子抑制扫视“坏”物体的能力。因此，间接通路介导了对坏选择的拒绝，这是目标导向行为的一个关键组成部分。
