利血平化增强电惊厥治疗对皮质α1肾上腺素能受体的作用。
Reserpinization enhances electroconvulsive treatment effects on cortical alpha 1-adrenoceptors.
作者信息
Pilc A, Nalepa I, Vetulani J
机构信息
Institute of Pharmacology, Polish Academy of Sciences, Kraków.
出版信息
Eur J Pharmacol. 1988 Nov 22;157(2-3):231-4. doi: 10.1016/0014-2999(88)90388-3.
Repeated electroconvulsion shock (ECS) for 7 days given to mildly reserpinized rats strongly elevated the density of [3H]prazosin-labelled alpha 1-adrenoceptors and depressed the EC50 for norepinephrine-stimulated inositol phosphate accumulation, while the effects of either treatment given alone were small or negligible. Alterations in alpha 1-adrenoceptor activity caused by ECS could possibly be a function of receptor sensitivity during drug treatment.
对轻度利血平化的大鼠连续7天给予重复电惊厥休克（ECS），可显著提高[3H]哌唑嗪标记的α1 -肾上腺素能受体的密度，并降低去甲肾上腺素刺激的肌醇磷酸积累的半数有效浓度（EC50），而单独给予这两种处理中的任何一种的效果都很小或可忽略不计。ECS引起的α1 -肾上腺素能受体活性的改变可能是药物治疗期间受体敏感性的一种表现。
Zotero 插件